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OPRL1 gene associated with more PTSD

June 11, 2013 Leave a comment

 

English: Cases of PTSD and Severe Depression A...

English: Cases of PTSD and Severe Depression Among U.S. Veterans Deployed to Iraq and Afghanistan Between Oct 2001 and Oct 2007 (Photo credit: Wikipedia)

It’s nice information to know if a certain gene can be associated with PTSD, if you have the gene you and your family could take extra steps in compensating for stressful events rather than expecting people to “buck up”.

This article shows that the use of a particular undisclosed drug kept people from having PTSD like symptoms in mice.  The drug works by activating the OPRL1 receptor for a brain chemical called nociceptin.   When the receptor was activated the mice learned not to feel fear.

In humans the presence of a particular SNP of that same gene had more pronounced PTSD symptoms.

So one version of the gene can protect you while another version may not.  And it seems that morphine  acts on a receptor that’s related, by that I assume close to, OPRL1.

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