ADHD and Executive Function

January 27, 2013 Leave a comment
Human Eye with different lines. The line of si...

Human Eye with different lines of sights.

We know that ADHD exists, so I’m not going to go into proofs that the child is not “raised irresponsibily”.  On the other hand, having a child with any disability does require you to be a more sophisticated parent and more sympathetic.

Executive Function (EF)

Executive Functions or EF are the skills used to filter, organize, and prioritize stimulus and cognition to perform a function.  Kids with ADHD  “exhibited significant impairment on neuropsychological
measures of response inhibition, vigilance, working memory, and planning”.   

Tests

From the neuropsych perspective, the Wisconsin Card Sort,  the Rey–Osterreith, and the Tower of Hanoi have been used to test EF.  You may have seen these tests on the Neuropsych Report when you had your child tested at the psychologists office.

EF part of ADHD or IS ADHD?

The International Journal of Disability, Development and Education, published a paper about how ADHD can be looked at with respect to EF with two perspectives: 1) Executive Function is part of the ADHD diagnosis or 2) Executive Function is the reason you have ADHD in the first place. 

Many meta studies have shown that while there is weakness of executive functioning in a part of the ADHD population it is not a singular representation of ADHD behaviors and outcomes.  Some studies show that only 30% of those diagnosed with ADHD have executive functioning problems.  And  people with autism, oppositional defiant, traumatic brain injury and other disorders also show EF problems.

Others like Denckla, Barkley, T.E. Brown and others show that there is significant cognitive impact, especially the ability to inhibit.  Brown has modeled the areas where this cognitive deficit can be seen:

  1. Activation: Organising, prioritising and activating to work.
  2. Focus: Focusing, sustaining, and shifting attention to tasks.
  3. Effort: Regulating alertness, sustaining effort, and processing speed.
  4. Emotion: Managing frustration and regulating emotions.
  5. Memory: Utilising working memory and accessing recall.
  6. Action: Monitoring and self-regulating action.

Brown argues that tests traditionally used in a neuropsych report are insufficient indicators of EF strengths.  The reason for this is that dissecting a problem into constituent parts is reductionist and does not reflect the whole.  While you can put body parts together and add electricity, you will not get a whole functioning human from it.  Rather a test of normal daily functions is a better indicator of EF ability.

Stealth Dyslexia

Sometimes EF problems can result from Stealth Dyslexia.  Have you or child made “stupid mistakes”?  You know that 3+12=15, but on a test you may multiply the left hand side and come up with an answer of 36, and not know you made the mistake.  Even if you go back and check.  Dyslexia originally thought to be a reading disorder may manifest in several ways not currently recognized as dyslexia.  What if the dyslexia manifested cognitively outside of just reading?  Eides and Eides have determined that Stealth Dyslexia have these in common:

  • Characteristic dyslexic difficulties with word processing and written output.  This is sometimes found as high IQ and verbal comprehension but trouble with output: terseness, spelling mistakes etc.
  • Findings on neurological and neuropsychological testing consistent with the visual language, auditory, and motor processing deficits characteristic of dyslexia.  Visual Percepetion issues and not attention could be the cause of coding/tracking problems.  Visual Problems can often be addressed by seeing a Developmental Optometrist.  Central Auditory Processing Disorder (CAPD) is found in many kids (and adults) where one cannot manage and filter background sounds from primary communication.
  • Reading skills that appear to fall within the normal or even superior range for children their age, at least on silent reading comprehension.  But writing and listening may be problematic.  Sometimes one can tape the lecture knowing that ideas will be recorded for later recall, several times if needed.   That way one can listen to the lecture and absorb the concepts.

Processing Speed

Yes slow processing speed is a recognized condition and can contribute to the impulsivity of ADHD.  People with SPS (I just made that up), cannot participate in dynamic conversations because just as they’ve figured out the pace, direction and tone, it has moved on.  They also have trouble “getting” things that are taught.  You might find very intelligent people teaching themselves, and rather than get behind they teach themselves ahead of everyone else. If you cannot keep up, you might just  forget it and decide to go for things.  And this may become a habit, that manifest as EF.  Some studies show that processing speed normalizes around 27 years of age, but if you can’t wait that long…or have regressed because of TBI, you can consider neurofeedback or SimplySmarter which works on sequential processing  and therefore could help processing speed in general. 

Medications have not been known to help with any of these things that interfere with clear EF, but knowledge of these aspects may allow you to have the sympathy to support your child (spouse?) better.

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Categories: Affect/Emotion, Anxiety, Autism

Chronic Fatigue as a Response to Organ Failure

January 23, 2013 12 comments

 In 2004 a patient of Dr. Cheney, Carol Silverling wrote down her interpretations of the cardiac dynamics of CFS.  Her article was based on interviews with Dr. Cheney and her own knowledge.CS

The premise is that because of mercury poisoning or viruses we are creating too much peroxynitrite which causes oxidation and aging Reduced microcirculation as a result of the mercury  begins to cause organ failure.  In “normal” people this may result in a fast path to organ transplant (or death), but for others (those who have CFS)  it results in organ failure in a progressive slower fashion.  This means you have time to address the problems! 

Heart Failure

Dr. Cheney’s premise is that every CFS individual is in the process of heart failure, this is termed Idiopathic Cardiomyopathy (ICM). The difference between CFS and heart failure is that the body is trying to compensate for the lack of microcirculation  by symptoms found in CFS. 

 Dr. Natelson applied for an NIH grant to find physiological parameters that may independently be a measure for the degree of disability. The purpose of this was to find a quantifiable way to designate those that are disabled from those that are not.  But also a measure of the degree of disability…how disabled are you? This could be significant in a “two-sides-of-the-same-coin” kind of way.  With an objective marker you could not fool anyone into providing disability services that were not needed.

And on the other side, you could get disability services even though you “don’t look sick”. The measure they looked at was “Q”, which stand for cardiac output in liters per minute.  CFS individuals have the largest variation of Q when they stand up.  This lowered Q could result in organ failure due to low cardiac output.  In this measure the higher the score the greater the disability.  Using an FDA approved algorithm to measure impedance of blood,  they determined this Q measure.  The idea was that the Q value would be adjusted for size of the individuals so that the it was a true measure of disability across the population and body types.

There is a another statistic that correlates with Q, and that is post extertional fatigue (PEF).  This is not the “no pain, no gain” kind of pain you want while building muscle. This is a breakdown and can’t repair kind of muscle ache.  As it turns out all disabled CFS patients have PEF. 

At the same time you may be aware of POTS (Postural Orthostatic Tachycardia Syndrome). There are several kinds of POTS, but one is when one stands up and  the drop in blood pressure is large enough that the heart must compensate by beating faster.  The reason for the drop is that the end arteriole or resistance vessel was not doing its job of moving  blood up against gravity from your feet.  When this is not working your body also tries to compensate by increasing the pressure to get it moving.  When this occurs the main line (to the heart)  improves but peripheral blood is not moving optimally and microcirculation is decreased.    These compensations by the heart are just that — compensations.

Organ Failure Progession

Peripheral organs fail first without enough Q, but they are sacrified in priority.  Here is that priority in normal circumstances. See if this lines up with the progession of illnesses in yourself or family/friend:

  • Skin and hypothyroidism. The skin and nails are at the extreme “end” of your body and therefore will suffer the most from loss of microcirculation. Now you can’t regulate your temperature from your skin so your body turns down your thyroid ON PURPOSE.  Your skin which is one way to detox is now unable to do this and so detox through sauna is often recommended.
  • Muscles.  Not only do you get pain when you exercise, you get NO GAIN.  The more capillaries (like male athletes have) the less likely this is going to happen, and if you are a sedentary female…well you can guess. This is because women have fewer capillaries then men on average and based on the  lack of activity do not grow (or maintain the ones you have).  This could explain how with intense exercise you are still unable to gain muscle.
  • Gut.  Since your gut needs microcirculation to function, you won’t be able to digest, and will develop food allergies, and be unable to detoxify.  You could get flatulence, constipation and all sorts of overgrowths.  Less digestion also means less absorption. 
  • Brain.  As the master controller of your bodily functions if this doesn’t work, neither does anything else really.  You could get autonomic problems to hypothalamus regulation of hormones, decreased processing speed, memory and cognition.  The combination of thinking and being sedentary (office work anyone?) is the worst possible combination.  Meditation might help those who are sedentary, but even slow deliberate exercise would be good.  In the worst cased you could get a rebounder, a small trampline and just bounce on it.
  • Heart.  Now your heart struggles with even the smallest amount of exertion, if the microcirculation problems get worse your hearty heart cells begin to die.  If  this in turn causes more microcirulation problems you have begun a feedback loop of cardiac failure. 
  • Kidneys and Lungs are the last to go and are considered the cause of death.  The only thing that can save you is a transplant.  In CFS though it’s different. You may have most of the early steps, but you don’t end up with extreme pulmonary edema and renal failure.

Causes

ICM can often caused by infectious diseases; Dr. Cheney thinks there might be a link to some viruses.  The other contributing factor could be heavy metal poisoning.  An Italian study found that ICM hearts had 23K times more mercury than control and 18K more mercury than other types of heart disease.

Peroxynitrite

Dr. Pall has another angle on CFS and that is Peroxinitrite.

NO + Super Oxide = Peroxinitrite

Peroxynitrite is deadly and this is the celluar cause of “old age” and death.  However it is made from two compounds that are essential for life, Nitrous Oxide (NO) and Superoxide (SO). Peroxynitrite participates in oxidation with free radical formation. Dr. Pall studied these dynamics in CFS which can be explained as follows:

Nitrous Oxide  (NO)

 There are three kinds of Nitrous Oxide, iNOS, eNOS and nNOS. iNOS is created to fend off bugs and allergies.  eNOS is for microcirculation, and nNOS is for memory and learning, but also makes you sensitive to (Electro Magnetic Radiation) EMR and noise. The NMDA receptor makes NO when activated; some practitioners use GABA to downregulate NMDA.

Superoxide (SO)

is made while manufacturing energy, in the mitichondria. NO is found outside the mitochondria, thus NO and SO have no way of interacting with each other to create peroxynitrite. Until SO starts to leak out.  Within the mitochondria, SO should be broken down by SOD before leaking out, but this assumes that glutathione is present.  If you have the CBS mutation you may not be making enough glutathione.  If you are very toxic, the glutathione you make might be attending to other problems and not be around to help.

Mercury can block the binding site of selenium on a cell and therefore not allow the SO to be broken down, now it begins to leak out of the cell. The more energy you generate the more SO begins to leak in the presence of mercury. Eventually having not enough glutathione will result in injury to the mitochondria membrane.

CoQ10 in the mitochondria and ALA in the cytoplasma bind to SO to prevent leaking out and unable to form peroxinitrite in the when it does.  CoQ10 is tricky in that there is an optimum amount and taking more than that you may generate more SO than you wanted. (It appears that Idebenone may be better than CoQ10 in that case) 

Without CoQ10 and ALA to help, your body stops making energy in order to reduce the creation of peroxynitrite.  Provigil is often used to create energy by activating the NMDA receptor, but this is creating more NO, which can contribute  to peroxynitrite in the presence of SO. 

So what gets rid of peroxynitrite once it is created?  CO2.  CO2 is a peroxynitrite scavenger and is created when ATP is made. Normally this would work great, but as ATP is reduced (because peroxinytrite is not being scavenged) so is CO2 and thus the scavenging of Peroxynitrite gets reduced further.

You can increase CO2 by rebreathing your own breath. This will also improve microcirculation.  Have you notice you or family member sleeping comfortably entirely under the covers?  Could this be the mechanism going on?

How do you reduce NO and SO?

    1. Klonopin gets rid of the enzyme that creates NO.
    2. You could live at or below sea level to increase CO2. POTSIES often feel better at these elevations.
    3. Uric acid is a scavenger of peroxynitrite and is found to be low in CFS.  It is made from RNA and DNA metabolism, and fasting!  So those religious folks had it right. 
    4. Sushi is very high in digestible RNA and DNA. Microwaving kills RNA and DNA efficiently.   You can also eat “young food” such as eggs and raw milk. If you can’t get raw milk consider raw milk cheeses.  Nuts and seeds and baby lettuces and spinach as well.
    5. B12 injections (if you have the MTHFR mutation this means Methyl B12 injections)
    6. Magnesium Sulfate blocks NO production. Finally you can take Zinc and Selenium to block and/or chelate mercury.  

I really found this topic very interesting.  It explains a progression of symptoms that are familiar and for me points back to mercury being the culprit.  Luckily we have ways to remove the mercury even if is a complex process.  Other ways to help with microcirculation in the meantime are L-Arginine and Black Pepper Essential Oils.  

In summary, instead of running headlong into heart failure, PWCFS are going through the same progression just much slower…giving us time to maybe address the problem.

EMDR for PTSD

January 21, 2013 1 comment
EMDR

EMDR

EMDR stands for Eye Movement Desensitization and Reprocessing, originally coined by Dr. Francine Shapiro Ph.D.  She had been recalling  her own traumatic event while taking a walk, and realized that when her eye movements went from side-to-side that the  feelings and “pull” of that event lessened noticeably.   She then decided to investigate the dynamics further and  developed an 8 stage approach to EMDR.   To summarize the patient is creates a safe place in their imagination for retreat if any trauma is found to be overwhelming during the session.  Once this has been established the patient is brought back to the negative memories while they watch a light move from side to side.  After each movement session, the client reevaluates to see if the positive cognition (a preferred alternate to the same situation) is true.  When the client is satisfied that the positive cognition is true and the negative is not, the session is “installed” in the body through the client scanning their body and attend to any physical discomfort.

Does EMDR Work?

This processes then was studied several times by Dr. Shapiro and several  other researchers.  Even critics of the method still agree that there is a positive response, it is more a matter of whether eye movements are central to the therapeutic effects.  The evidence for the work is handily summarized  in a Q&A with Dr. Shapiro and the New York Times readers.   Some believe that desensitization was the key dynamic, while others claim that the eye movements are analogous to R.E.M. sleep eye movements  and this is how trauma is processed.  These studies have been supported by the American Psychiatric Association  (for example for rape) as well as the Department of Defense for soldiers returning from war.

Personal Response

Having done a lot of work on myself,  medically, psychologically and with nutrition, I felt that whatever was slowing down my progress must be subsconscious.  I asked my therapist if she knew anyone trained in other types of techniques such as hypnosis and found she was trained by Dr. Shapiro.  So we did our own sessions,  I ended up needing only 5 sessions for me to process what I was consciously aware of.   It was highly successful, and as a result I was able to move onto another level of self discovery entirely positive.

Variations

More than Eyes

Since the original discovery of EMDR, it has been found that the same effect can be had by using sound or touch on both sides of the body.  So while advancement is not dependent on eyes, it seems that the bilaterality is the key.  It appears that the bilaterality is a method of creating new flows that bypass the “stuck feeling” in the psyche and allow resolutions

Brainspotting

Brainspotting

Brainspotting

Brainspotting, a book by David Grand is a technique that extends that found in  EMDR .  The author used EMDR to address most of his trauma, but could not find a way to resolve it completely.  He realized that there was a location in an individual’s visual field that could be identified by patterns in eye movement when the patient looked in that direction and rested there.  These signify unresolved processes that are held in the brain, very much like one can hold trauma in the body.  The patient is guided to attend to this location and be with the trauma, then observe and watch the dynamics change as one follows the changes.  The brain is now able to process the trauma so it loses its hold and now becomes a memory.

Worth Trying

Bothe EMDR and Brainspotting are thought to be efficient ways to address trauma that is held in the brain.  They each require a lot less time that talk therapy and seem to have evidence to back up their efficacy.   If you decide to try it, please let us know how you did!

Categories: Affect/Emotion, Trauma

High Blood Pressure

January 19, 2013 1 comment

 A little info about High Blood Pressure prevelance, symptoms and treatment options.

Prevalence

High Blood Pressure is known as a silent killer.  You may not know that you have it, but for it to be even slightly elevated there may be problems.  73.6 million people in the U.S.  have high blood pressure,  that’s one in four people and the CDC says one in three adults.  And it’s not just for old people, one in ten of men between the ages of 25-34 have it!  Why are rates increasing in younger people?  There could be a couple of reasons:   When I was younger upto 140/90 was still considered normal, now it is considered Stage 1 Hypertension, so it may be recategorization.  It seems that the obesity epidemic is contributing to more cases of HBP, as more younger people gain weight.

There tends to be more HBP in men then in women, and is highly correlated with heart disease, stroke, inflammation, allergies, headaches and fatigue among others.  While some say that there is not a genetic component there is a correlation with high homocysteine, and the MTR, CBS and MTHFR gene mutations can impact homocysteine levels.  As one ages your capillaries can lose their flexibility and that creates higher blood pressure.

Poor diet, and stressful lifestyles can also contribute to high blood pressure, and this is situational hypertension rather than the slow progression seen in aging.  Anger is another example of situational high blood pressure, that you may be able to address with therapy or meditation/spirituality.

Associations with Other Conditions

In addition to those mentioned above, do check out your blood presure if you have been diagnosed with metabolic syndrome or are hypothyroid.

Symptoms

Though it is considered a silent killer,  do consider being mindful of your blood pressure if you have the following symptoms

Fatigue Cluster headaches
nosebleed tinnitus
numbness tingling weakness
palpitation frequent urination
blurred vision confusion memory loss
chest pains dizziness
muscle cramps exessive perspiration
Irritability brain aging

Treatment

 

In addition to blood pressure medication you have the the following options you might want to try.  Sometimes medications can cause edema and other symptoms, so you could try these to see if the medication dose can be reduced if not eliminted

Herbs

  • You may consider going to your local herb shop and getting a blood pressure blend.  These will typically contain Hawthorn, which has been known to alleviate HBP.
  • Rauwolfia  has been used in India to control HBP for a long time, it can be found in Cardiotone and homeopathically

Nootropics

Pyritinol, which is an analog of Vitamin B6 has been known to bring down blood pressure fast.  It is considered an antiaging drug and can be found on antiaging sites.  It is also known as Cerbon 6.

Essential Oils have been studied and purported to reduce high blood pressure.  You could consider cold diffusing Ylang Ylang, Lavender, Lemon

Potassium-rich foods

  • Purple Potatoes
  • Beet Juice
  • Celery
  • Apples
  • Red Wine..or grape juice?

Supplements

  • Fish Oil , you can freeze these before swallowing if you otherwise burp fish oil
  • Vit C, CoQ10,Vit E ( but not too much)
  • Ginger, Garlic, Cayenne
  • Fiber
  • Calcium and magnesium
  • Aspirin for inflammation reduction and blood thinning
  • Music for relaxation and anger
  • Stop Smoking!
  • Meditation andPets for reducing stress

Monitor

Do consider purchasing a blood pressure monitor, and possibly a Wrist Monitor, if your arms are too bulky for the regular ones, and monitor weekly if you’re on the border and daily if you are already on medication.  Make sure to empty your bladder before doing this, because it may affect your readings.

Remember that your blood pressure may rise if stressed, or if you are traveling and eating out more (they add sodium to food out there you know).  If you are daily readings you may be able to correlate with events

Drink more water; you may think water is boring, so may be perk it up by putting in some lemon or spiking it with an essential oil you may like.

Cheers,

Metabolic Dysfunction..Why Sugar is Bad

January 16, 2013 1 comment

Don’t want to watch 1.5 hours of video?  Let me summarize why Dr. Lustig  a pediatric endocrinologist thinks  sugar is bad. The obese are not perpetrators they are victims of their biochemistry and fructose.  There are fat genes, but that is not what is being covered today..

Debunking 30 years of Nutrition in America

Atkins Diet: All Fat no Carb,  Japanese: All Carbs No Fat.  Both succeed, why?  They both  eliminate Fructose

We all weigh 25lbs more today than 25 years ago.  Genes are the same, but environment has changed.  1st Law of Thermodynamics (calories in/calories out):  WRONG. 

If something lowers your energy expenditure (Hypothyroidsm, starvation) you feel like crap, if it raises it (coffee), you feel good.  Kids do not choose to be obese.  There is an epidemic of obese 6 month olds, so how do you blame intentions of a 6 month old.  This is happening worldwide.

We are eating more, but why?  Leptin is supposed to slow down the appetite, but it isn’t working.  It’s a negative feedback loop that’s not working.  The greater calories are coming from carbs.  In order to reduce fat, we started to eat carbs.  Lowered fats correlates with greater obesity.  It’s the carbs, not fat.

Carbs are coming from soft drinks and fruit drinks in children.  1915 first bottle had 6.5 oz of coke in a bottle, now we have big gulps for ONE person  44oz.  Sugar is cheap now.  Coke has a diuretic, and caffeine, both make you thirsty.  Salt also makes your thirsty. Coke has enough salt as a pizza.  The sugar covers all this up so you don’t know you are getting dehydrated.

When soda machines were removed from high schools, levels obesity leveled out, those with soda machines continued to rise. Another study shows that soft drinks correlated with Type 2 diabetes, but not orange and grapefruit juice. Soft drinks contain….

High Fructose Corn Syrup

Why does HFCS even exist?  because it’s even cheaper than sugar. 63lbs per person/year.  If you give table sugar an index of 100, HFCS has n index of 173 for sweetness. (Glucose is 74)  You would think you can take less of it, instead in processed food,  there is a lot of it.

Sucrose (table sugar) has  Glucose and Fructose in a 1:1 ratio.   HFCS and Sucrose are both equally bad. Sucrose is bad because it contains Fructose.  Fructose  is a poison, It’s not about the calories:  Since WWII we are not just eating more, we are eating more sugar. It is now 15% of calories from fructose.

Branched Chain Amino Acids (BCAA) also has problems but they were not delved into.

Perfect Storm

  1. Nixon in 1972 told USDA Secretary to make food a non issue ,because there was too much fluctation in food prices.  Therefore USDA began to try to make food cheap
  2. HFCS made by Japanese scientist in 1966 and introduced to US in 1975 became a cheap way to do this.  Now HFCS is in almost every processed food. Juice also causes Type 2 Diabetes.  Juice comes from food stamps in the poor.
  3. 1982 USDA, AMA told us to reduce our consumption of fat to stop heart disease.  We did and now we have more heart disease.  One study led us to this conclusion and it was based on the following stepwise logic: 
    1. Dietary Fat raises LDL
    2. LDL correlates with cardiovascular
    3. Therefore cut out dietary fat

 

But correlation is not causation.

PureWhiteDeadly1972

Joh Yedkin wrote this book in 1972 by endocrinologist.

John Yedkin, an endocrinologist wrote this book in 1972, claiming tha sugar is poisonous.

Another guy Ancel Keys found there was a correlation of CHD with saturated fats…but foods with fats also had sugar along with them.  So is it fat or sugar?  When Keys did his multivariate linear analysis, he found a correlation in one direction: high fat is associated with heart disease, but not the other: heart disease is associated with high fat.  So the conclusion of avoiding saturated fats is actually not supportable.

Also there are two kinds of LDL, so which kind of LDL cause damage?  Pattern A or Pattern B?   Pattern A is when the LDL moleculres are so bouyant they can’t cause plaque in arteries.  Pattern B are the ones that begin to create plaque. The way to distinguish is through the use of triglyceries and HDL.

If low Triglycerides, and high HDL -> good (Pattern A)

High Triglycerides, low HDL->  bad (Pattern B)

Dietary fat raises HDL (good), sugar raises LDL(bad).  Now the low fat craze has resulted in more sugar, and more transfats.

Biochemistry

  • Fructose 7 times more likely to have the browing reaction (AGE)
  • Fructose does not satiate hunger by suppressing ghrelin
  • Does not stimulate insulin or leptin
  • Hepatic processing is completely different
    • causes metabolic syndrome

Comparisons

  • When eating 2 slices of white bread:80% of that is glucose, which we are designed to eat. Glucagon and Epinephrine convert it to glycogen, which is a nontoxic storage form.  Some of it becomes pyruvate  for mitochondria to make ATP. Some of it could become citrate and goes to 3 enzymes  that turn sugar into fat: Denovo Lipogenesis, which creates VLDL (Bad [heart disease and obesity]). 24 calories can participate in the lipogenesis.
  •  Ethanol(alchohol) is a toxin Alcohol causes acute problems in brain, but frucose does not cause acute problems. 120 calories of ethanol, 24 calories are used up  right away.  96 calories hit liver unlike the 24  in sugar.  Alcohol is converted into aldehydes, and damages protein in liver, but will generate energy.  More Citrate available because more calories in general, so more VLDL.  Liver will try to get rid of it, sometimes in the form of free fatty acids resulting in muscle insulin resistance and diabetes.  Then it generates JUNK1 which creates inflammation.
  • 120 calories of sucrose (orange juice): 20/80 split for glucose, but all fructose molecules will go to liver.  No insulin is made,  We now have 72 calories that must be phosphorylated (so phosphorous is lost), and creates uric acid (gout, and hypertension).  Uric Acid blocks enzyme endothelial NO Synthase, blocking NO.   NO keeps your blood pressure low.   Alpurinol treats gout by treating uric acid and blood pressure went down.

Fructose also repletes glycogen faster than sugar….but this is for elite athletes, not kids.  Original gatorade was terrible, so they added HFCS.  Now we have another path that also makes citrate and therefore VLDL.

Fructose makes fat, Glucose does not.

Fructose makes fat, Glucose does not.

Sugar makes fat, so high sugar diet is a functionally a high fat diet.  ALT is an enzyme that tells you if you have a fatty liver.  The more sugar the more ALT.  JUNK1 inactivates the ability to use the sugar in liver, and makes energy goes into fat cell; increases insulin.  All this causes 8/12 sympoms of chronic ethanol exposure. Biochemically sugar and alcohol are functionally the same

Treatment

  • No juice/sugar beverages
  • Eat Carb with Fiber
  • Wait 20 mintes for before getting another portion
  • Buy screen time 1:1 with physical activity

It works!

Exercise

Is important because it improves insulin sensitivity. reduces stress, make the deNovo lipogenesis ( by increasing the TCA cycle)

Fiber

Antidote to sugar. Fruit is ok because of  fiber and micro nutrients.

  • Reduces carbohydrate absorption:farts
  • Increase rate of transit to illium
  • Short Chain Fatty Acids suppress insulin

Paleo

cures diabetes because of fiber, not because of the meat but because of the fiber in the vegetables.  But if you’d like to cut down on the suga:  FrenchFries, Hash Browns, Chicken McNuggets, Diet Coke, Coffee,Sausage. have no sugar @ McDonalds.

Coke, Beer have same effect on liver

Coke, Beer have same effect on liver.

Soda Belly == Beer Belly

Fructose is a carbohydate, but metabolized as a fat, thus a low fat diet is not a low fat diet.  Should not be GRAS, no studies show that it is safe.  FDA only regulates acute toxins, not chronic toxins.

Summary

 

  • GTT: Insulin Hyper secretion
  • ALT:  amt of liver fat
  • Uric Acid: proxy for sugar consumption
  • Fat makes you fat, but sugar pushes you metabolic syndrome
  • Glucose is good sugar but not that sweet
  • Fructose ontains keto groups that create browining reaction.  Protein get less flexible
  • Fruit is better than juice.  Because fruit has fiber, and slows down sugar absorption
  • Eating less will not work if there is leptin resistance.  Insulin causes this leptin resistance.
    • Eat less sugar/fructose
    • if Hypersecretion fewer carbs
    • exercise creates mitochondria to burn fat
  • Antipsychotic drugs and obesity, T2D
    • Mood Stabilizers causes liver insulin resistance
    • and weight gain
  • We eat too much sugar (toxid doses)
    • comes hidden in processed foods
    • and soft drinks
    • Sugar doesn’t cause obesity, it causes metabolic syndrome
  • Nothing sweet is poisonous…so it is safe
  • Fructose and Glucose together causes more fat than just fructose
    • Fructose goes down lipid pathway
    • Glucose Glycolitic pathway
  • artificial sugar increases weight?
    • no data (stevia)
    • Sugar bolus is coming, buth then insulin doesn’t come out and you end up overeating
  • Every diet regresses to the mean in 2 months.
  • Low Sugar and High fat
  • Yogurt (processed)  is not a health food
  • Liposuction does not remove visceral fat
  • Tumors respond/grow because of insulin
  • Not
    • total number of calories
    • fiber is pushes calories down alimentary canal so not absorbed
    • fats are good for you, while transfat are bad
    • Proteins…you expend more energy breaking down proteins than sugars (lower “net carbs”)
    • two kinds of meat..marbling IS insulin resistance in our food

 

Categories: Inflammation, Liver

Cancer is declining, so get your vaccinations?

January 12, 2013 Leave a comment

Overall lung, colon, breast, prostate are going down.  The CDC reports death rates for all cancers have been declining.   So get your vaccinations?

Causes of cancer can be inborn genetics, epigenetics as from smoking or environmental exposure like chemicals (are vaccines chemicals?)

Some of the reduction in cancers  may be as a result of prescreening. For example in Colon Cancer you can screen with a sigmoid scope, a colonscope or regular frequent stool testing.  Once you have reached a certain age you are automatically screened for cancers.  If you have diabetes and cannot afford to go off your meds, then the scoping may be replaced by regular frequent stool testing. 

HPV

On the other hand HPV is said to be increasing. From what to what?  Here’s a figure from the CDC about mortality from HPV, that is declining.

Cervical Cancer Deaths alling

Cervical Cancer Deaths over time

The current plan is to vaccinate against HPV. All prepubescent girls are hounded to get vaccinated and now the emphasis has moved to boys as well.  Preventing cancer is always good, and recently it appears that HPV causes more than cervical cancer.  It can also affect Vulva, Penis, Mouth and Throat Cancers.  7500 men out 150,000,000 get the cancer.  It’s not clear how many men die of that cancer, but just the number that have it, is exceedingly small .005%.

When asked about causes, it is  always “you get the virus from other people who have the virus”.  Well….how did they get the virus?

Whether you are for or against vaccines, you must admit that there is an assumption that your immune and detox systems can eliminate the vaccines and it’s adjuvants and chemicals to confer benefit.  If your system cann,t there may be other consequences…like Cancer.  But that is another discussion.  The cons against HPV vaccinations are

    • it prevents a type of cancer that is very rare to begin with, especially for boys ( though they can pass it onto girls).
    •  it prevents a type of cancer that can be easily caught and treated by promoting regular gynecological exams.  4000 out 150,000,000 women died of cervical cancer in 2009, that is .0026%.  This rate is attributed to the use of Pap Smears not vaccinations.
    • Safe Sex practices is a common sense method to avoid HPV
    • it is promoted to girls years before becoming sexually active, however because the vaccine is new it is not clear when individuals should revaccinated. Some say that the vaccines only confers benefits for 5-8 years.  So you are running out of protection just as you really ramp up your sexual life?   HPV is not alone  in being found to lose its effectiveness and need boosters.  Chicken Pox anyone?
    • it prevents 2 strains (strain 16 and 18) out of more than 100 strains of HPV (Strains 6 and 11 cause genital warts ).  16 and 18 are the ones that cause most cancers (70%), however infections do not automatically become cancersMost infections go away on their own in 1-2 years

      Snijders PJ, Steenbergen RD, Heideman DA, Meijer CJ (2006). “HPV-mediated cervical carcinogenesis: Concepts and clinical implications”. J. Pathol. 208 (2): 152–64. doi:10.1002/path.1866. PMID 16362994. “cervical cancer is a rare complication of an HPV infection since most such infections are transient, not even giving rise to cervical lesions.”

    • So far it has NOT been proven safe over the long haul….because there hasn’t been a long haul yet
    • Interestingly Harold Varmus director of the National Cancer Institute made a freudian slip when he said that HPV vaccinations “sterilize both boys and girls“.  He corrected himself for the record.
    • Then look at this article about it’s effectiveness. http://blogs.discovermagazine.com/crux/2011/11/23/how-effective-is-the-hpv-vaccine-at-preventing-cancer-a-closer-look/

Other Cancer Points

Generally different cancers have different approaches to treatment.   For instance in Leukemia in adults  a single change in a particular gene was found to be the cause.  When a drug targets the genes to turn it off the symptoms stop.  Even so some are becoming resistant to this drug.  So it’s another race (like antibiotics), to create new drugs as they become ineffective.

Other methods we are familiar with: chemo, radiation and surgery.  But even these are improving, the side effects of traditional methods are bone marrow suppression, pain, nausea/vomiting, and these seem to be improving.  Advances have let some people  function and work even while having cancer compared to traditional treatments.

Other methods for cancer treatment involve leveraging  the natural accelerators and brakes within your immune system.  These are being tested in leukemia and melanoma for example.  These treatments don’t work on all cancers and so far work short term… but Science marches on.

Cancer Avoidance

You already know, right?  Eat Right and Exercise?   But more specifically you should look for the inflammation marker CRP to start.  Inflammation is tied to cancer.  Also please don’t feed the cancer.  What does cancer like for lunch?  Sugar.  Your body can make its own sugar when needed so there’s really no need to take it.    Then again moderation is really important; you can have some dessert here and there.  But you must train your body not to expect it.

Vegetables.  Another option that Drs say have been studied, but hasn’t been proven is the use of veggies/juicing (and coffee enemas) to detox such as the Gerson protocol.  And so far Green Tea has not been shown to help with cancers.  This is based on mixed results. 

Avoid Super Foods.  Watson of  the DNA Duo Watson and Crick is saying that too many antioxidants are not good for you either.  They may cause cancer!  So free radicals may be needed to fend of cancer.  Interesting!

Take a Break.   Other studies find that intermittent dosing of cancer drugs may be more powerful than continuous treatment.

Baby Aspirin.  Baby aspirin is not just good for your heart.  There is a 30% reduction in cancer deaths  in the middle aged for lung, espophagus, stomach cancers.   If Aspirin doesn’t agree with you can try Wintergreen Essential Oil instead!

So it appears screening works, but it’s not clear why with few cases of cervical cancer, declining numbers of deaths, and other options, that vaccination is necessary.

The Myths of Happiness

January 6, 2013 Leave a comment

I heard a review of this book on the radio, and thought you may be interested in the discussion. Sonya Lyubomirsky is a psychologist who has studied happiness. She has found that happiness is not “attainable” but rather a state that is maintained regardless of the highs and lows in ones life.

I’ll be Happy When

I get that job, get that girl, get that money, have that house, have that baby.  But those big events only give you a bump in terms of happiness, the little things over a sustained basis are the ones that really affect your happiness. Whether negative or positive.  So little bursts of daily positive things will help you more than winning the lottery.

Is Happiness Important?

Hedonic Adaptation means that human beings adjust to whatever pleasure/happiness they have in their lives.  Got a bigger car, fantastic!  The afterglow won’t last that long, because even with that car, you will go back to your normal level of happines.  This could mean that you are always searching for another fix…or you could accept your level of happiness and not try to live at that level of stimulation (and potentially become antisocial in the process).  So it turns out there is a set point for happiness.

What about Striving?

If we were all happy with our situation…I’m looking at you meditators, would we ever try or enjoy anything?  Why go to the moon?  Why find cures for diseases?     It turns out that the heritability index for happiness is 50%.  Which means the half of things that make you happy are NOT your genes. 

Making You Happy

Smile

What helps you get happy (or stay happy) is,  Relationships!  Primary, Seconary and Tertiary: Family, Friends and Associates.  Studies have shown that the poorest societies are still happy because of close family connections.  Richer societies often loosen the family connection when wealth arrives.  Nonetheless there is a certain level of wealth that removes draining problems and this contributes to more happiness.  It’s just that dynamic of happiness creation has a limit.  Which is why more and more wealth does not lead to ultimate satisfaction.  Spending the money on worthy causes can contribute to happiness!  According to the book, the happiest countries are in Latin America (7/10), probably up and coming in terms of wealth but maintaining strong social bonds.

But what is happiness anyway?  It has two components: Frequent Positive Emotions and that you are progressing towards your life goals.

This means that people’s happiness is subjective.  An introvert can be happy with limited social interaction while an extrovert would suffer at the same level, and vice versa.   However generally speaking extroverts are on average happier than extroverts.

 There is also a level of happiness that comes through contrast, such as only being able to pet a favorite animal once a day (hedonic adaptation in reverse).  Could this be why many spiritual leaders give away their stuff rather than hoarding it?   Why start the hedonic snowball?

I’m not happy

If you are already not happy, how can you get it back? 

  • Do things you like
  • Serve others, volunteer, or bake!
  • Stay away from social comparison (Facebook)
  • Remember it’s the journey and not the destination
  • Replay good memories
  • don’t dwell on bad ones
  • Join a supportive group (like church, masjid, book club!)
Categories: Affect/Emotion, Anxiety Tags:
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