Archive for the ‘Organ’ Category

Macadamia and Omega 7 Fatty Acids

June 21, 2018 Leave a comment

So I was listening to Dr. Lindsey Berkson she has so many gems on her podcast, that I thought I would start at least writing them down.  For this one she was mentioning that Macadamia nuts are a source of Omega 7 fatty acids.  Well I haven’t heard of that before.  What is it?

Like Omega 6 acids are where a large fatty acid molecule has its first double bond at position 6, in this case the first bond is in position 10.  It’s also monounsaturated, like Olive Oil and helps reduce inflammation.

Omega-3 & Omega-6 fatty acids

Common versions of this type of fatty sacid are palmitoleic acid and vaccenic acid.  In a pilot study, palmitoleic acid has been known to reduce inflammation for people with Ulcerative Colitis in 8 weeks by regulating certain genes. In another study it can help reduce excessive triglycerdies and other lipids,  and may even have local hormonal effect as a lipokine.   Finally a small amount can have a large effect on factors of Metabolic Syndrome.

  1. It reduces insulin resistance
  2. suppress fat production and accumulation
  3. normalizes lipids
  4. fights obesity
  5. suppresses inflammation

Which means it can keep you off the trajectory towards cancer, diabetes, liver failure, heart disease,  etc.

Makes me want to rush out and get some Macdamia Nuts or Sea Buckthorn. I have read that these two food sources, the oils of these foods may have a lot of palmitic acid which counters these benefits.  So in summary I thinkt taking the whole food as a nut or berry might be the safest way to approach this.



Chris Wark Square One Day 2 — Causes of Cancer

June 16, 2018 Leave a comment

Hi there,

I took some notes on this excellent video series that I purchased. You should definitely watch the videos, they are presented well and he provides references.

He noted that the rates of cancer exploded after industrialization and implied that we have to reduce toxicity. This toxicity can come in forms such as

  1. Diet and Life Style
  2. Environment
  3. Stress

I am acutely aware of all these categories.  In a way the first two could be rolled into the last one.:  Stress.

Carrying onhe also breaks down diseased to two types:

  1. Infectious Diseases
  2. Chronic Diseases

Infectious Diseases

These used to cause a lot of suffering but with increases in sanitation and hygiene this have been reduced and now only 5% of deaths happen because of these.

Chronic Diseases

According to Chris 18-20% of cancers are linked to infections.  If your immune system is depressed than viruses that would otherwise cause problems can flare.

  • Of these viruses the Bovine Leukemia virus is found in milk and meat.  37% of breast cancer may be attributed to this virus.
  • H Pylori bacteria can contribute to stomach cancer because it converts nitrites into cancer causing compounds in the gut.

Global Cancer Incidences

There are some linkages between diet and cancer.  One data point is that in Japan many cancers were lower and they ate less than 5% of their diet as meat. In addition some African nations have lower cancer rates as show in this map.

Global Cancer Rates 2012

Diet and Lifestyle

Chris believes that higher fiber and starchy vegetables help to detox.  Starch absorbs toxins and uses bile to help it leave the body.  If they don’t leave they can get reabsorbed and become precancerous.   Items such as beans, peas, lentils, corn, rice, potatoes, millet, spelt, teff, wheat carrots, beets, turnips, cabbage, collard greens, mustard greens, sweet potatoes will help you detox during digestion.

In addition their diet saves meat for special occasions, doesn’t use a lot of salt or oils.  Especially if they are 90% GMO like corn, soy and canola. So you know I’m avoiding those.

Obesity is the 2nd leading cause of cancer it weakens your body as fat produces extra hormones.  We already know about cigarettes and lung cancer, but once the toxins get into your blood stream they can poison the lung colon, or anywhere the blood takes it.



Speaking of GMO non-GMO crops are sprayed with Glyphosate just before harvesting, these are

  • Wheat
  • Millet
  • Flax
  • Rye
  • Buckwheat
  • Barley
  • Oats
  • Bean
  • Peas
  • Lentils
  • Corn
  • Potatoes

So what’s wrong with Glyphosate? It disrupts the immune system.  It is absorbed by the plant itself and then the molecule is eaten by you.

So eat grains but not Glyphosate Grains. This means organic grains.


Ok let me be short, avoid drugs alcohol, prescriptions drugs such as birth control pills, hormones and blood pressure pills.  Easier said than done, but these pills don’t necessarily solve your problem they bring temporary relief giving us time to find other options.  For example my mom who is almost 80 has high blood pressure and is on 2 medications and they were not working well.  Now we have decided to use a fermented beet product and she has dropped 30 points.  If this continues rather than starting a 3rd medication she maybe be able to move down to 1.

Many drugs inhibit melatonin production.  Light pollution such as when using screens can also disrupt melatonin rhythms



Water has used chlorine and other chemicals to get rid of bacteria and infectious diseases, this is great!  But the chlorine it is not necessary to ingest or absorb the chlorine so getting whole house or sink/shower filters may be a good idea.  These filter don’t usually get rid of fluoride which is added to water under questionable circumstances.  I use a Berkey water filter which comes with a carbon attachment and an extra fluoride attachment.  I’m now thinking of using a Propur filter as a replacement, it might work better and it is easier to change one filter rather than two.


Ok we know pollution is bad, but since the industrial revolution we have also invented thousands of chemicals most of which are untested.  Air pollution is huge source of pollution, and you can’t get away from it by moving away because it dissipates generally.  If you move to the country you will encounter fertilizers and antifungals (and glyphosate?).  Even groundwater could be polluted.  I’m thinking of getting an IQ room air filter.  But you can avoid polluting your indoor environment by taking your shoes off at the entrance.

Also using non toxic cleaning products, air fresheners and body care products can go a long way in alleviating a toxic burden.  I’m using products made with essential oils as a first stop. Phthalates and parabens found in unregulated cosmetics  are cancer causing.  One can go to to see if they home care product has been tested .

Bottom line is if the body is busy detoxing and not succeeding it doesn’t have the energy to kill Cancer.

Ok whew!  Addressing stress will come in a separate post.

Categories: Cancer, Gut, Stress

Metabolic Dysfunction..Why Sugar is Bad

January 16, 2013 1 comment

Don’t want to watch 1.5 hours of video?  Let me summarize why Dr. Lustig  a pediatric endocrinologist thinks  sugar is bad. The obese are not perpetrators they are victims of their biochemistry and fructose.  There are fat genes, but that is not what is being covered today..

Debunking 30 years of Nutrition in America

Atkins Diet: All Fat no Carb,  Japanese: All Carbs No Fat.  Both succeed, why?  They both  eliminate Fructose

We all weigh 25lbs more today than 25 years ago.  Genes are the same, but environment has changed.  1st Law of Thermodynamics (calories in/calories out):  WRONG. 

If something lowers your energy expenditure (Hypothyroidsm, starvation) you feel like crap, if it raises it (coffee), you feel good.  Kids do not choose to be obese.  There is an epidemic of obese 6 month olds, so how do you blame intentions of a 6 month old.  This is happening worldwide.

We are eating more, but why?  Leptin is supposed to slow down the appetite, but it isn’t working.  It’s a negative feedback loop that’s not working.  The greater calories are coming from carbs.  In order to reduce fat, we started to eat carbs.  Lowered fats correlates with greater obesity.  It’s the carbs, not fat.

Carbs are coming from soft drinks and fruit drinks in children.  1915 first bottle had 6.5 oz of coke in a bottle, now we have big gulps for ONE person  44oz.  Sugar is cheap now.  Coke has a diuretic, and caffeine, both make you thirsty.  Salt also makes your thirsty. Coke has enough salt as a pizza.  The sugar covers all this up so you don’t know you are getting dehydrated.

When soda machines were removed from high schools, levels obesity leveled out, those with soda machines continued to rise. Another study shows that soft drinks correlated with Type 2 diabetes, but not orange and grapefruit juice. Soft drinks contain….

High Fructose Corn Syrup

Why does HFCS even exist?  because it’s even cheaper than sugar. 63lbs per person/year.  If you give table sugar an index of 100, HFCS has n index of 173 for sweetness. (Glucose is 74)  You would think you can take less of it, instead in processed food,  there is a lot of it.

Sucrose (table sugar) has  Glucose and Fructose in a 1:1 ratio.   HFCS and Sucrose are both equally bad. Sucrose is bad because it contains Fructose.  Fructose  is a poison, It’s not about the calories:  Since WWII we are not just eating more, we are eating more sugar. It is now 15% of calories from fructose.

Branched Chain Amino Acids (BCAA) also has problems but they were not delved into.

Perfect Storm

  1. Nixon in 1972 told USDA Secretary to make food a non issue ,because there was too much fluctation in food prices.  Therefore USDA began to try to make food cheap
  2. HFCS made by Japanese scientist in 1966 and introduced to US in 1975 became a cheap way to do this.  Now HFCS is in almost every processed food. Juice also causes Type 2 Diabetes.  Juice comes from food stamps in the poor.
  3. 1982 USDA, AMA told us to reduce our consumption of fat to stop heart disease.  We did and now we have more heart disease.  One study led us to this conclusion and it was based on the following stepwise logic: 
    1. Dietary Fat raises LDL
    2. LDL correlates with cardiovascular
    3. Therefore cut out dietary fat


But correlation is not causation.


Joh Yedkin wrote this book in 1972 by endocrinologist.

John Yedkin, an endocrinologist wrote this book in 1972, claiming tha sugar is poisonous.

Another guy Ancel Keys found there was a correlation of CHD with saturated fats…but foods with fats also had sugar along with them.  So is it fat or sugar?  When Keys did his multivariate linear analysis, he found a correlation in one direction: high fat is associated with heart disease, but not the other: heart disease is associated with high fat.  So the conclusion of avoiding saturated fats is actually not supportable.

Also there are two kinds of LDL, so which kind of LDL cause damage?  Pattern A or Pattern B?   Pattern A is when the LDL moleculres are so bouyant they can’t cause plaque in arteries.  Pattern B are the ones that begin to create plaque. The way to distinguish is through the use of triglyceries and HDL.

If low Triglycerides, and high HDL -> good (Pattern A)

High Triglycerides, low HDL->  bad (Pattern B)

Dietary fat raises HDL (good), sugar raises LDL(bad).  Now the low fat craze has resulted in more sugar, and more transfats.


  • Fructose 7 times more likely to have the browing reaction (AGE)
  • Fructose does not satiate hunger by suppressing ghrelin
  • Does not stimulate insulin or leptin
  • Hepatic processing is completely different
    • causes metabolic syndrome


  • When eating 2 slices of white bread:80% of that is glucose, which we are designed to eat. Glucagon and Epinephrine convert it to glycogen, which is a nontoxic storage form.  Some of it becomes pyruvate  for mitochondria to make ATP. Some of it could become citrate and goes to 3 enzymes  that turn sugar into fat: Denovo Lipogenesis, which creates VLDL (Bad [heart disease and obesity]). 24 calories can participate in the lipogenesis.
  •  Ethanol(alchohol) is a toxin Alcohol causes acute problems in brain, but frucose does not cause acute problems. 120 calories of ethanol, 24 calories are used up  right away.  96 calories hit liver unlike the 24  in sugar.  Alcohol is converted into aldehydes, and damages protein in liver, but will generate energy.  More Citrate available because more calories in general, so more VLDL.  Liver will try to get rid of it, sometimes in the form of free fatty acids resulting in muscle insulin resistance and diabetes.  Then it generates JUNK1 which creates inflammation.
  • 120 calories of sucrose (orange juice): 20/80 split for glucose, but all fructose molecules will go to liver.  No insulin is made,  We now have 72 calories that must be phosphorylated (so phosphorous is lost), and creates uric acid (gout, and hypertension).  Uric Acid blocks enzyme endothelial NO Synthase, blocking NO.   NO keeps your blood pressure low.   Alpurinol treats gout by treating uric acid and blood pressure went down.

Fructose also repletes glycogen faster than sugar….but this is for elite athletes, not kids.  Original gatorade was terrible, so they added HFCS.  Now we have another path that also makes citrate and therefore VLDL.

Fructose makes fat, Glucose does not.

Fructose makes fat, Glucose does not.

Sugar makes fat, so high sugar diet is a functionally a high fat diet.  ALT is an enzyme that tells you if you have a fatty liver.  The more sugar the more ALT.  JUNK1 inactivates the ability to use the sugar in liver, and makes energy goes into fat cell; increases insulin.  All this causes 8/12 sympoms of chronic ethanol exposure. Biochemically sugar and alcohol are functionally the same


  • No juice/sugar beverages
  • Eat Carb with Fiber
  • Wait 20 mintes for before getting another portion
  • Buy screen time 1:1 with physical activity

It works!


Is important because it improves insulin sensitivity. reduces stress, make the deNovo lipogenesis ( by increasing the TCA cycle)


Antidote to sugar. Fruit is ok because of  fiber and micro nutrients.

  • Reduces carbohydrate absorption:farts
  • Increase rate of transit to illium
  • Short Chain Fatty Acids suppress insulin


cures diabetes because of fiber, not because of the meat but because of the fiber in the vegetables.  But if you’d like to cut down on the suga:  FrenchFries, Hash Browns, Chicken McNuggets, Diet Coke, Coffee,Sausage. have no sugar @ McDonalds.

Coke, Beer have same effect on liver

Coke, Beer have same effect on liver.

Soda Belly == Beer Belly

Fructose is a carbohydate, but metabolized as a fat, thus a low fat diet is not a low fat diet.  Should not be GRAS, no studies show that it is safe.  FDA only regulates acute toxins, not chronic toxins.



  • GTT: Insulin Hyper secretion
  • ALT:  amt of liver fat
  • Uric Acid: proxy for sugar consumption
  • Fat makes you fat, but sugar pushes you metabolic syndrome
  • Glucose is good sugar but not that sweet
  • Fructose ontains keto groups that create browining reaction.  Protein get less flexible
  • Fruit is better than juice.  Because fruit has fiber, and slows down sugar absorption
  • Eating less will not work if there is leptin resistance.  Insulin causes this leptin resistance.
    • Eat less sugar/fructose
    • if Hypersecretion fewer carbs
    • exercise creates mitochondria to burn fat
  • Antipsychotic drugs and obesity, T2D
    • Mood Stabilizers causes liver insulin resistance
    • and weight gain
  • We eat too much sugar (toxid doses)
    • comes hidden in processed foods
    • and soft drinks
    • Sugar doesn’t cause obesity, it causes metabolic syndrome
  • Nothing sweet is poisonous…so it is safe
  • Fructose and Glucose together causes more fat than just fructose
    • Fructose goes down lipid pathway
    • Glucose Glycolitic pathway
  • artificial sugar increases weight?
    • no data (stevia)
    • Sugar bolus is coming, buth then insulin doesn’t come out and you end up overeating
  • Every diet regresses to the mean in 2 months.
  • Low Sugar and High fat
  • Yogurt (processed)  is not a health food
  • Liposuction does not remove visceral fat
  • Tumors respond/grow because of insulin
  • Not
    • total number of calories
    • fiber is pushes calories down alimentary canal so not absorbed
    • fats are good for you, while transfat are bad
    • Proteins…you expend more energy breaking down proteins than sugars (lower “net carbs”)
    • two kinds of meat..marbling IS insulin resistance in our food


Categories: Inflammation, Liver

Inflammation and Depression

December 31, 2012 1 comment
Dahlia 'Inflammation'

Dahlia ‘Inflammation’ (Photo credit: F. D. Richards)

According to this Danish post, inflammation causes depression, which causes inflammation.  Depression causes one to have errant sleep, poor stress management, eating poorly, withdrawl from socials support.  This causes epigenetic changes that increase inflammation.

Danish scientists took a cohort of 73,000 people and measured their levels of C-Reactive Protein (CRP)…a marker for inflammation, and mapped those levels to antidepressant dispensation from a pharmacy, and records of people hospitalized for depression.  (You will never be able to do something like this in the USA). 

They found that people with CRP above 3mg/liter had more antidepressant use and hospitalization than those with values under 1mg/liter.  CRP is made in the liver. While the article says that inflammation may affect serotonin in the brain.  We know that serotonin is also found in the GI tract….right next to that liver.  So it must be affected there as well?

 So many more reasons to monitor inflammation, and reduce it.   I suspect that inflammation is our body overextended.  Designed to solve problems here and there such as in injuries, prolonged stress may lead to continuous inflammation.  So stress reduction may be a great way to reduce CRP and maybe therefore depression..

Liver and Circadian Cycles

December 30, 2012 1 comment

Liver & Onions

There are over 3000 switches that turn genes off or on in the liver on a daily basis.

Did you know that circadian rhythms affect our bodies not just on a global scale, but at the level of individual organs, and even genes? UVA has found two different cycles, with he newest one based on genes that are active in the liver.  These genes are responsive to nutrient intake rather than being light-based like the ones in the brain.

Since the liver is involved in metabolism of cholesterol and fat, this finding may help isolate the switches or combination of swiches that contribute to this processing.

This article states: they discovered that among those switches was chromatin, the protein complex that tightly packages DNA in the cell nucleus. While chromatin is well known for the role it plays in controlling genes, it was not previously suspected of being affected by circadian cycles.

So it is through circadian effect on chromatin that some epigenetic control might be occuring.  Histonic.  No that’s not a misspelling. Histones have been found to be responsible for genetic epression.  We just didn’t know it was based on circadian rhythms!

On that note I’m planning on changing my sleep schedule and go to bed now… before midnight!

Categories: Genetics, Liver, Organ, Sleep
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