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Chronic Fatigue as a Response to Organ Failure

January 23, 2013 12 comments

 In 2004 a patient of Dr. Cheney, Carol Silverling wrote down her interpretations of the cardiac dynamics of CFS.  Her article was based on interviews with Dr. Cheney and her own knowledge.CS

The premise is that because of mercury poisoning or viruses we are creating too much peroxynitrite which causes oxidation and aging Reduced microcirculation as a result of the mercury  begins to cause organ failure.  In “normal” people this may result in a fast path to organ transplant (or death), but for others (those who have CFS)  it results in organ failure in a progressive slower fashion.  This means you have time to address the problems! 

Heart Failure

Dr. Cheney’s premise is that every CFS individual is in the process of heart failure, this is termed Idiopathic Cardiomyopathy (ICM). The difference between CFS and heart failure is that the body is trying to compensate for the lack of microcirculation  by symptoms found in CFS. 

 Dr. Natelson applied for an NIH grant to find physiological parameters that may independently be a measure for the degree of disability. The purpose of this was to find a quantifiable way to designate those that are disabled from those that are not.  But also a measure of the degree of disability…how disabled are you? This could be significant in a “two-sides-of-the-same-coin” kind of way.  With an objective marker you could not fool anyone into providing disability services that were not needed.

And on the other side, you could get disability services even though you “don’t look sick”. The measure they looked at was “Q”, which stand for cardiac output in liters per minute.  CFS individuals have the largest variation of Q when they stand up.  This lowered Q could result in organ failure due to low cardiac output.  In this measure the higher the score the greater the disability.  Using an FDA approved algorithm to measure impedance of blood,  they determined this Q measure.  The idea was that the Q value would be adjusted for size of the individuals so that the it was a true measure of disability across the population and body types.

There is a another statistic that correlates with Q, and that is post extertional fatigue (PEF).  This is not the “no pain, no gain” kind of pain you want while building muscle. This is a breakdown and can’t repair kind of muscle ache.  As it turns out all disabled CFS patients have PEF. 

At the same time you may be aware of POTS (Postural Orthostatic Tachycardia Syndrome). There are several kinds of POTS, but one is when one stands up and  the drop in blood pressure is large enough that the heart must compensate by beating faster.  The reason for the drop is that the end arteriole or resistance vessel was not doing its job of moving  blood up against gravity from your feet.  When this is not working your body also tries to compensate by increasing the pressure to get it moving.  When this occurs the main line (to the heart)  improves but peripheral blood is not moving optimally and microcirculation is decreased.    These compensations by the heart are just that — compensations.

Organ Failure Progession

Peripheral organs fail first without enough Q, but they are sacrified in priority.  Here is that priority in normal circumstances. See if this lines up with the progession of illnesses in yourself or family/friend:

  • Skin and hypothyroidism. The skin and nails are at the extreme “end” of your body and therefore will suffer the most from loss of microcirculation. Now you can’t regulate your temperature from your skin so your body turns down your thyroid ON PURPOSE.  Your skin which is one way to detox is now unable to do this and so detox through sauna is often recommended.
  • Muscles.  Not only do you get pain when you exercise, you get NO GAIN.  The more capillaries (like male athletes have) the less likely this is going to happen, and if you are a sedentary female…well you can guess. This is because women have fewer capillaries then men on average and based on the  lack of activity do not grow (or maintain the ones you have).  This could explain how with intense exercise you are still unable to gain muscle.
  • Gut.  Since your gut needs microcirculation to function, you won’t be able to digest, and will develop food allergies, and be unable to detoxify.  You could get flatulence, constipation and all sorts of overgrowths.  Less digestion also means less absorption. 
  • Brain.  As the master controller of your bodily functions if this doesn’t work, neither does anything else really.  You could get autonomic problems to hypothalamus regulation of hormones, decreased processing speed, memory and cognition.  The combination of thinking and being sedentary (office work anyone?) is the worst possible combination.  Meditation might help those who are sedentary, but even slow deliberate exercise would be good.  In the worst cased you could get a rebounder, a small trampline and just bounce on it.
  • Heart.  Now your heart struggles with even the smallest amount of exertion, if the microcirculation problems get worse your hearty heart cells begin to die.  If  this in turn causes more microcirulation problems you have begun a feedback loop of cardiac failure. 
  • Kidneys and Lungs are the last to go and are considered the cause of death.  The only thing that can save you is a transplant.  In CFS though it’s different. You may have most of the early steps, but you don’t end up with extreme pulmonary edema and renal failure.

Causes

ICM can often caused by infectious diseases; Dr. Cheney thinks there might be a link to some viruses.  The other contributing factor could be heavy metal poisoning.  An Italian study found that ICM hearts had 23K times more mercury than control and 18K more mercury than other types of heart disease.

Peroxynitrite

Dr. Pall has another angle on CFS and that is Peroxinitrite.

NO + Super Oxide = Peroxinitrite

Peroxynitrite is deadly and this is the celluar cause of “old age” and death.  However it is made from two compounds that are essential for life, Nitrous Oxide (NO) and Superoxide (SO). Peroxynitrite participates in oxidation with free radical formation. Dr. Pall studied these dynamics in CFS which can be explained as follows:

Nitrous Oxide  (NO)

 There are three kinds of Nitrous Oxide, iNOS, eNOS and nNOS. iNOS is created to fend off bugs and allergies.  eNOS is for microcirculation, and nNOS is for memory and learning, but also makes you sensitive to (Electro Magnetic Radiation) EMR and noise. The NMDA receptor makes NO when activated; some practitioners use GABA to downregulate NMDA.

Superoxide (SO)

is made while manufacturing energy, in the mitichondria. NO is found outside the mitochondria, thus NO and SO have no way of interacting with each other to create peroxynitrite. Until SO starts to leak out.  Within the mitochondria, SO should be broken down by SOD before leaking out, but this assumes that glutathione is present.  If you have the CBS mutation you may not be making enough glutathione.  If you are very toxic, the glutathione you make might be attending to other problems and not be around to help.

Mercury can block the binding site of selenium on a cell and therefore not allow the SO to be broken down, now it begins to leak out of the cell. The more energy you generate the more SO begins to leak in the presence of mercury. Eventually having not enough glutathione will result in injury to the mitochondria membrane.

CoQ10 in the mitochondria and ALA in the cytoplasma bind to SO to prevent leaking out and unable to form peroxinitrite in the when it does.  CoQ10 is tricky in that there is an optimum amount and taking more than that you may generate more SO than you wanted. (It appears that Idebenone may be better than CoQ10 in that case) 

Without CoQ10 and ALA to help, your body stops making energy in order to reduce the creation of peroxynitrite.  Provigil is often used to create energy by activating the NMDA receptor, but this is creating more NO, which can contribute  to peroxynitrite in the presence of SO. 

So what gets rid of peroxynitrite once it is created?  CO2.  CO2 is a peroxynitrite scavenger and is created when ATP is made. Normally this would work great, but as ATP is reduced (because peroxinytrite is not being scavenged) so is CO2 and thus the scavenging of Peroxynitrite gets reduced further.

You can increase CO2 by rebreathing your own breath. This will also improve microcirculation.  Have you notice you or family member sleeping comfortably entirely under the covers?  Could this be the mechanism going on?

How do you reduce NO and SO?

    1. Klonopin gets rid of the enzyme that creates NO.
    2. You could live at or below sea level to increase CO2. POTSIES often feel better at these elevations.
    3. Uric acid is a scavenger of peroxynitrite and is found to be low in CFS.  It is made from RNA and DNA metabolism, and fasting!  So those religious folks had it right. 
    4. Sushi is very high in digestible RNA and DNA. Microwaving kills RNA and DNA efficiently.   You can also eat “young food” such as eggs and raw milk. If you can’t get raw milk consider raw milk cheeses.  Nuts and seeds and baby lettuces and spinach as well.
    5. B12 injections (if you have the MTHFR mutation this means Methyl B12 injections)
    6. Magnesium Sulfate blocks NO production. Finally you can take Zinc and Selenium to block and/or chelate mercury.  

I really found this topic very interesting.  It explains a progression of symptoms that are familiar and for me points back to mercury being the culprit.  Luckily we have ways to remove the mercury even if is a complex process.  Other ways to help with microcirculation in the meantime are L-Arginine and Black Pepper Essential Oils.  

In summary, instead of running headlong into heart failure, PWCFS are going through the same progression just much slower…giving us time to maybe address the problem.

Cancer is declining, so get your vaccinations?

January 12, 2013 Leave a comment

Overall lung, colon, breast, prostate are going down.  The CDC reports death rates for all cancers have been declining.   So get your vaccinations?

Causes of cancer can be inborn genetics, epigenetics as from smoking or environmental exposure like chemicals (are vaccines chemicals?)

Some of the reduction in cancers  may be as a result of prescreening. For example in Colon Cancer you can screen with a sigmoid scope, a colonscope or regular frequent stool testing.  Once you have reached a certain age you are automatically screened for cancers.  If you have diabetes and cannot afford to go off your meds, then the scoping may be replaced by regular frequent stool testing. 

HPV

On the other hand HPV is said to be increasing. From what to what?  Here’s a figure from the CDC about mortality from HPV, that is declining.

Cervical Cancer Deaths alling

Cervical Cancer Deaths over time

The current plan is to vaccinate against HPV. All prepubescent girls are hounded to get vaccinated and now the emphasis has moved to boys as well.  Preventing cancer is always good, and recently it appears that HPV causes more than cervical cancer.  It can also affect Vulva, Penis, Mouth and Throat Cancers.  7500 men out 150,000,000 get the cancer.  It’s not clear how many men die of that cancer, but just the number that have it, is exceedingly small .005%.

When asked about causes, it is  always “you get the virus from other people who have the virus”.  Well….how did they get the virus?

Whether you are for or against vaccines, you must admit that there is an assumption that your immune and detox systems can eliminate the vaccines and it’s adjuvants and chemicals to confer benefit.  If your system cann,t there may be other consequences…like Cancer.  But that is another discussion.  The cons against HPV vaccinations are

    • it prevents a type of cancer that is very rare to begin with, especially for boys ( though they can pass it onto girls).
    •  it prevents a type of cancer that can be easily caught and treated by promoting regular gynecological exams.  4000 out 150,000,000 women died of cervical cancer in 2009, that is .0026%.  This rate is attributed to the use of Pap Smears not vaccinations.
    • Safe Sex practices is a common sense method to avoid HPV
    • it is promoted to girls years before becoming sexually active, however because the vaccine is new it is not clear when individuals should revaccinated. Some say that the vaccines only confers benefits for 5-8 years.  So you are running out of protection just as you really ramp up your sexual life?   HPV is not alone  in being found to lose its effectiveness and need boosters.  Chicken Pox anyone?
    • it prevents 2 strains (strain 16 and 18) out of more than 100 strains of HPV (Strains 6 and 11 cause genital warts ).  16 and 18 are the ones that cause most cancers (70%), however infections do not automatically become cancersMost infections go away on their own in 1-2 years

      Snijders PJ, Steenbergen RD, Heideman DA, Meijer CJ (2006). “HPV-mediated cervical carcinogenesis: Concepts and clinical implications”. J. Pathol. 208 (2): 152–64. doi:10.1002/path.1866. PMID 16362994. “cervical cancer is a rare complication of an HPV infection since most such infections are transient, not even giving rise to cervical lesions.”

    • So far it has NOT been proven safe over the long haul….because there hasn’t been a long haul yet
    • Interestingly Harold Varmus director of the National Cancer Institute made a freudian slip when he said that HPV vaccinations “sterilize both boys and girls“.  He corrected himself for the record.
    • Then look at this article about it’s effectiveness. http://blogs.discovermagazine.com/crux/2011/11/23/how-effective-is-the-hpv-vaccine-at-preventing-cancer-a-closer-look/

Other Cancer Points

Generally different cancers have different approaches to treatment.   For instance in Leukemia in adults  a single change in a particular gene was found to be the cause.  When a drug targets the genes to turn it off the symptoms stop.  Even so some are becoming resistant to this drug.  So it’s another race (like antibiotics), to create new drugs as they become ineffective.

Other methods we are familiar with: chemo, radiation and surgery.  But even these are improving, the side effects of traditional methods are bone marrow suppression, pain, nausea/vomiting, and these seem to be improving.  Advances have let some people  function and work even while having cancer compared to traditional treatments.

Other methods for cancer treatment involve leveraging  the natural accelerators and brakes within your immune system.  These are being tested in leukemia and melanoma for example.  These treatments don’t work on all cancers and so far work short term… but Science marches on.

Cancer Avoidance

You already know, right?  Eat Right and Exercise?   But more specifically you should look for the inflammation marker CRP to start.  Inflammation is tied to cancer.  Also please don’t feed the cancer.  What does cancer like for lunch?  Sugar.  Your body can make its own sugar when needed so there’s really no need to take it.    Then again moderation is really important; you can have some dessert here and there.  But you must train your body not to expect it.

Vegetables.  Another option that Drs say have been studied, but hasn’t been proven is the use of veggies/juicing (and coffee enemas) to detox such as the Gerson protocol.  And so far Green Tea has not been shown to help with cancers.  This is based on mixed results. 

Avoid Super Foods.  Watson of  the DNA Duo Watson and Crick is saying that too many antioxidants are not good for you either.  They may cause cancer!  So free radicals may be needed to fend of cancer.  Interesting!

Take a Break.   Other studies find that intermittent dosing of cancer drugs may be more powerful than continuous treatment.

Baby Aspirin.  Baby aspirin is not just good for your heart.  There is a 30% reduction in cancer deaths  in the middle aged for lung, espophagus, stomach cancers.   If Aspirin doesn’t agree with you can try Wintergreen Essential Oil instead!

So it appears screening works, but it’s not clear why with few cases of cervical cancer, declining numbers of deaths, and other options, that vaccination is necessary.

Orange Essential Oil as an Antihistamine

December 15, 2012 Leave a comment

Got allergies?  Maybe you have mast cell degranulation going on.   Usually taking antihistamines is the way to go, but for severe cases even they don’t work.  A testimonial at Oil-Testimonials.com claims that taking 10-20 drops of high quality Orange essential oil has had the same effect. 

Orange Blossom

Interestingly we already know that Vitamin C is also a potent anti-histamine.   And vitamin C is found in oranges!   My springtime allergies have completely receded because of this.  Wikipedia notes that 2 grams might be enough, but it’s better to follow this protocol:

  1. Take a small amount (50mg) of a vitamin C tablet and watch your symptoms.  You may find relief of symptoms or you may find loose stools.
  2. If no response, double your dose, or move up by 50mg  increments until you get to the point of loose stools.  When you reach that point, move down by 50mg increments until the loose stools go away.
  3. This is your maintenance dose

If your overall health improves (less stress) you may find that you might need to back down more.  If seasonal allergies come roaring in you might have to up the dose.  And generally speaking Vitamin C is good for colds and is held in reserve in your adrenals.  So there may be another advantage there.

 Good luck!

Mast Cell problems

July 24, 2012 Leave a comment

Mast cells are one type of cell that works as part of the immune system.  Mast Cells degranulate or open up and spill their granules.  These I think then are instrumental in raising histamine and otherwise responding to infections.  Bottom line is greater inflammation.  One way to reduce inflammation is through the use of Luteolin .  It has been shown to reduce inflammation and be neuroprotective.

So of course how do you get Luteolin.  “Luteolin is most often found in leaves, but it is also seen in celery, thyme, dandelion, rinds, barks, clover blossom, and ragweed pollen”.  Interesting that ragweed pollen is exactly the thing that often sends one into an allergic reaction some through mast cells .  I love to juice celery, but not sure what the ratio to product would be in a juice.  Probably the most  concentrated way of getting Luteolin would be through Thyme essential oil.  Wikipedia also says that “Dietary sources include celery, green pepper, thyme, perilla, chamomiletea, carrots, olive oil, peppermint, rosemary, navel oranges, and oregano“.

Now thyme, rosemary, peppermint and oregano are some of the oils that are used in the raindrop technique along the spine.  The others also underlined are also available through Young Living.   Although I give raindrop to people, this makes me think I need to get one myself!

Essential Oils for Lyme Disease

July 21, 2012 Leave a comment

I was on a local health group and someone had asked about alternative methods to control Lyme Disease. I had remembered listening to a woman who had Lyme for 15 years before she was treated. She had a specific protocol that she had used. So I sent this post off to certain members who showed interest:

“There are some recommendations/testimonials from people about how essential oils helped them and am responding to the request for alternative treatments. I didn’t want to post on the list because I consider it public, but will send this particular one which is the strongest. Because each person is different, please start low and slow,and after assessing that the healing reactions are acceptable one could accelerate usage. In addition you may find that after some time you may able to take more of a break between treatments.

This is from a woman who had lyme disease for 15 years before she started treatment and she used a multistep approach:
Raindrop Technique- this is a body technique where several essential oils are applied to the spine in a particular order using specific oils and massage techniques The person in question had done this once/week for 9 months. Within the 1st month her LLMD took her off of several supplements. Initially when you get the Raindrop you may feel better for a few days and then begin to taper off. As you continue you should see that the positive effects last longer. If the detoxification is happening you will need to drink LOTS of water.
Ningxia Red- This is a whole highly concentrated drink with a high ORAC score that provides bioavailable antioxidants. 1/oz per day. This is a general tonic.
Lyme Capsules. You can take empty vegetable capsules from the health food store and put the following EO drops into them and swallow. Every 4 hours for first 3 days. Every 8 hours for the rest of the 4 days for a week. Repeat this if you feel symptoms return and continue for 3 months (may be related to replicated cycle of particular spirochettes). Drink LOTS of water.
2 drops Frankincense
12 drops Thieves
6 drop Oregano
She also did a master cleanse afterwards

I have personally used the lyme capsules and can say I did not have any untoward effects. I have also used the Raindrop Technique on several people and they felt better, but they did not have Lyme. The oils used are Young Living brand which I trust internally. I wouldn’t use oils from the healthfood store unless they were labeled for internal use.

If you were getting a raindrop, the person giving it to you should have the oils, but if you wanted to try the capsule you would have to purchase the oils from someone. I became a distributor for my own use because of massive health problems that have not yet been diagnosed as lyme related.”

Rosemary for help with Alzheimers

Wow, wow, wow!

In summary: Early trials indicate that aromatherapy and meditation may be helpful to Alzheimer’s patients, as they have been shown to improve blood supply and enhance cognitive skills.

http://eiriu-eolas.org/2012/04/19/meditation-rosemary-oil-unusual-weapons-in-the-fight-against-alzheimers/

Categories: Essential Oils

Rosemary for better brain function

March 19, 2012 Leave a comment

20 healthy volunteers were tasked to perform cognitive functions in an area infused with the essential oil of rosemary.  The key constituent is 1,8-cineole, and in this case the more concentrated the better the performance!    There was a less significant correlation when it comes to mood as well.

Thank god my order from Young Living just arrived with Rosemary in it!

http://tpp.sagepub.com/content/early/2012/02/24/2045125312436573.abstract

Categories: Essential Oils
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