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Liver and Circadian Cycles

December 30, 2012 1 comment

Liver & Onions

There are over 3000 switches that turn genes off or on in the liver on a daily basis.

Did you know that circadian rhythms affect our bodies not just on a global scale, but at the level of individual organs, and even genes? UVA has found two different cycles, with he newest one based on genes that are active in the liver.  These genes are responsive to nutrient intake rather than being light-based like the ones in the brain.

Since the liver is involved in metabolism of cholesterol and fat, this finding may help isolate the switches or combination of swiches that contribute to this processing.

This article states: they discovered that among those switches was chromatin, the protein complex that tightly packages DNA in the cell nucleus. While chromatin is well known for the role it plays in controlling genes, it was not previously suspected of being affected by circadian cycles.

So it is through circadian effect on chromatin that some epigenetic control might be occuring.  Histonic.  No that’s not a misspelling. Histones have been found to be responsible for genetic epression.  We just didn’t know it was based on circadian rhythms!

On that note I’m planning on changing my sleep schedule and go to bed now… before midnight!

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Categories: Genetics, Liver, Organ, Sleep

Mercury levels are going up!

December 3, 2012 Leave a comment

And not just from vaccinations.

Dr. Hyman has the greatest video on mercury and health impacts such as

  • colitis
  • nervous system toxicity such as shyness or nervousness
  • parkinson’s like tremor
  • slurred speech
  • fatigue
  • depression
  • kidney toxicity
  • dermatitis

So where do you get mercury? 

  1. red tattoo dye
  2. contact lens fluid
  3. vaccines
  4. fish
  5. vapors
  6. mercury water
  7. dental fillings
  8. skin lightening creams

Dr. Hyman says it better than I can.

Categories: Anxiety, Depression, Sleep

Tricyclics for Mast Cell

October 22, 2012 2 comments

There are several tricyclics in the market.  These were used as antidepressants before SSRIs became popular.  They can help children who wet the bed when they get older, or help you sleep.   For me, I used it for sleep but lost interest in food.  This made for an easy diet and a 60lb effortless weightloss.  My friends worried that I did not have proper nutrition but I finally got my body to use my fat stores. Yeah! 🙂

Now what are mast cells? From Wikipedia:  “is a resident cell of several types of tissues and contains many granules rich in histamine and heparin. Although best known for their role in allergy and anaphylaxis, mast cells play an important protective role as well, being intimately involved in wound healing and defense against pathogens.[2]” 

Many people with POTS (Postural Orthostatic Tachycardia Syndrome) also have mast cell problems. This means there is a lot of inflammation and allergic reactions. This often manifests as skin inflammation, and for me sometimes I think it results in me taking  a “power nap” soon after eating items that activate mast cells.

Tricyclic antidepressants may be beneficial in CFS because of their ability to inhibit brain mast cell activation and release of proinflammatory molecules. (1)   Interestingly these happen in the brain.

There are several types of tricyclics.  The one I used is amitriptylene for sleep.  It takes about 6 weeks for it to go into full effect I lost weight easily and was not hungry.  Finally I saw that I was beginning to look gaunt. So I stopped sure that my weight gain would return….NOT!  Slowly I began to get an appetite again, and it was a normal hunger not craving.  Weight gain?  NOT!

It was only after 3 years, when under a lot of stress that my weight gain began and has continued steadily for the last 5 years.  I tried the amitryptiline again, but did not have the same effect :(.

Nonetheless, there is something significant about its effect. It may histamine related, maybe not.   Needs discovery.

Sleep and Fibromyalgia

April 15, 2012 Leave a comment

Gang,

A great set of videos from the National Fibromyalgia (FMS) and Chronic Pain Association.  They show how people with FMS have the sleep patterns of a very old person.  Interesting things found in the study include how FMS was induced into healthy college students my interrupting their deep sleep and mirroring “alpha intrustion”.  When alpha waves, found when awake, interrupt deep sleep.

Also shows the results of using  Sodium Oxybate improves sleep and (resulting?) pain from FMS, as monitored through the use of QEEG.  Sodium Oxybate (SXB) aka GHB, which is a metabolite of GABA.  It is approved for narcolepsy.   Has been shown using the gold standard of studies to show a statistically significant difference with placebo in the first week!  Also known as Xyrem.  GHB is illegal in many countries so it may be useful to take GABA, it’s precursor instead.  In the US it is legal for narcolepsy.

Watch the videos, which also compare to Benzodiazepines and Antihistamines.  The former are good for short term treatment but in the longer term actually interfere with deep sleep!

Also covers betablockers which may impair melatonin production.  SNRIs may help with pain, but sometimes worsen insomnia.  Energy drinks are a no-no.

In terms of obustructive sleep insomnia.

So you may consider buying a Zeo, which is a band that rests on your head while you sleep and sends a signal to a smart phone to track your sleep.  If you find interesting information there, you might consider getting a sleep study.

this snip from the presentation shows how if your airway is obstructed what happens to your body that then awakens you through sympathetic arousal and increased cortisol.    This could explain why I wake up in the middle of the night cursing because I forgot to do something.

The videos also cover:

  •  restless leg, which could be caused by an iron deficiency
  •  narcolepsy (caused by post-strep autoimmunity, that destroys the hypocretin/orexin cells of the hypothalamus. (Would hypothalamus glandulars help?).  Diagnosed by a daytime sleep study.

Check them out!

Categories: Anxiety, Sleep Tags:
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