Archive

Archive for the ‘Inflammation’ Category

High Blood Pressure

January 19, 2013 1 comment

 A little info about High Blood Pressure prevelance, symptoms and treatment options.

Prevalence

High Blood Pressure is known as a silent killer.  You may not know that you have it, but for it to be even slightly elevated there may be problems.  73.6 million people in the U.S.  have high blood pressure,  that’s one in four people and the CDC says one in three adults.  And it’s not just for old people, one in ten of men between the ages of 25-34 have it!  Why are rates increasing in younger people?  There could be a couple of reasons:   When I was younger upto 140/90 was still considered normal, now it is considered Stage 1 Hypertension, so it may be recategorization.  It seems that the obesity epidemic is contributing to more cases of HBP, as more younger people gain weight.

There tends to be more HBP in men then in women, and is highly correlated with heart disease, stroke, inflammation, allergies, headaches and fatigue among others.  While some say that there is not a genetic component there is a correlation with high homocysteine, and the MTR, CBS and MTHFR gene mutations can impact homocysteine levels.  As one ages your capillaries can lose their flexibility and that creates higher blood pressure.

Poor diet, and stressful lifestyles can also contribute to high blood pressure, and this is situational hypertension rather than the slow progression seen in aging.  Anger is another example of situational high blood pressure, that you may be able to address with therapy or meditation/spirituality.

Associations with Other Conditions

In addition to those mentioned above, do check out your blood presure if you have been diagnosed with metabolic syndrome or are hypothyroid.

Symptoms

Though it is considered a silent killer,  do consider being mindful of your blood pressure if you have the following symptoms

Fatigue Cluster headaches
nosebleed tinnitus
numbness tingling weakness
palpitation frequent urination
blurred vision confusion memory loss
chest pains dizziness
muscle cramps exessive perspiration
Irritability brain aging

Treatment

 

In addition to blood pressure medication you have the the following options you might want to try.  Sometimes medications can cause edema and other symptoms, so you could try these to see if the medication dose can be reduced if not eliminted

Herbs

  • You may consider going to your local herb shop and getting a blood pressure blend.  These will typically contain Hawthorn, which has been known to alleviate HBP.
  • Rauwolfia  has been used in India to control HBP for a long time, it can be found in Cardiotone and homeopathically

Nootropics

Pyritinol, which is an analog of Vitamin B6 has been known to bring down blood pressure fast.  It is considered an antiaging drug and can be found on antiaging sites.  It is also known as Cerbon 6.

Essential Oils have been studied and purported to reduce high blood pressure.  You could consider cold diffusing Ylang Ylang, Lavender, Lemon

Potassium-rich foods

  • Purple Potatoes
  • Beet Juice
  • Celery
  • Apples
  • Red Wine..or grape juice?

Supplements

  • Fish Oil , you can freeze these before swallowing if you otherwise burp fish oil
  • Vit C, CoQ10,Vit E ( but not too much)
  • Ginger, Garlic, Cayenne
  • Fiber
  • Calcium and magnesium
  • Aspirin for inflammation reduction and blood thinning
  • Music for relaxation and anger
  • Stop Smoking!
  • Meditation andPets for reducing stress

Monitor

Do consider purchasing a blood pressure monitor, and possibly a Wrist Monitor, if your arms are too bulky for the regular ones, and monitor weekly if you’re on the border and daily if you are already on medication.  Make sure to empty your bladder before doing this, because it may affect your readings.

Remember that your blood pressure may rise if stressed, or if you are traveling and eating out more (they add sodium to food out there you know).  If you are daily readings you may be able to correlate with events

Drink more water; you may think water is boring, so may be perk it up by putting in some lemon or spiking it with an essential oil you may like.

Cheers,

Advertisements

Metabolic Dysfunction..Why Sugar is Bad

January 16, 2013 1 comment

Don’t want to watch 1.5 hours of video?  Let me summarize why Dr. Lustig  a pediatric endocrinologist thinks  sugar is bad. The obese are not perpetrators they are victims of their biochemistry and fructose.  There are fat genes, but that is not what is being covered today..

Debunking 30 years of Nutrition in America

Atkins Diet: All Fat no Carb,  Japanese: All Carbs No Fat.  Both succeed, why?  They both  eliminate Fructose

We all weigh 25lbs more today than 25 years ago.  Genes are the same, but environment has changed.  1st Law of Thermodynamics (calories in/calories out):  WRONG. 

If something lowers your energy expenditure (Hypothyroidsm, starvation) you feel like crap, if it raises it (coffee), you feel good.  Kids do not choose to be obese.  There is an epidemic of obese 6 month olds, so how do you blame intentions of a 6 month old.  This is happening worldwide.

We are eating more, but why?  Leptin is supposed to slow down the appetite, but it isn’t working.  It’s a negative feedback loop that’s not working.  The greater calories are coming from carbs.  In order to reduce fat, we started to eat carbs.  Lowered fats correlates with greater obesity.  It’s the carbs, not fat.

Carbs are coming from soft drinks and fruit drinks in children.  1915 first bottle had 6.5 oz of coke in a bottle, now we have big gulps for ONE person  44oz.  Sugar is cheap now.  Coke has a diuretic, and caffeine, both make you thirsty.  Salt also makes your thirsty. Coke has enough salt as a pizza.  The sugar covers all this up so you don’t know you are getting dehydrated.

When soda machines were removed from high schools, levels obesity leveled out, those with soda machines continued to rise. Another study shows that soft drinks correlated with Type 2 diabetes, but not orange and grapefruit juice. Soft drinks contain….

High Fructose Corn Syrup

Why does HFCS even exist?  because it’s even cheaper than sugar. 63lbs per person/year.  If you give table sugar an index of 100, HFCS has n index of 173 for sweetness. (Glucose is 74)  You would think you can take less of it, instead in processed food,  there is a lot of it.

Sucrose (table sugar) has  Glucose and Fructose in a 1:1 ratio.   HFCS and Sucrose are both equally bad. Sucrose is bad because it contains Fructose.  Fructose  is a poison, It’s not about the calories:  Since WWII we are not just eating more, we are eating more sugar. It is now 15% of calories from fructose.

Branched Chain Amino Acids (BCAA) also has problems but they were not delved into.

Perfect Storm

  1. Nixon in 1972 told USDA Secretary to make food a non issue ,because there was too much fluctation in food prices.  Therefore USDA began to try to make food cheap
  2. HFCS made by Japanese scientist in 1966 and introduced to US in 1975 became a cheap way to do this.  Now HFCS is in almost every processed food. Juice also causes Type 2 Diabetes.  Juice comes from food stamps in the poor.
  3. 1982 USDA, AMA told us to reduce our consumption of fat to stop heart disease.  We did and now we have more heart disease.  One study led us to this conclusion and it was based on the following stepwise logic: 
    1. Dietary Fat raises LDL
    2. LDL correlates with cardiovascular
    3. Therefore cut out dietary fat

 

But correlation is not causation.

PureWhiteDeadly1972

Joh Yedkin wrote this book in 1972 by endocrinologist.

John Yedkin, an endocrinologist wrote this book in 1972, claiming tha sugar is poisonous.

Another guy Ancel Keys found there was a correlation of CHD with saturated fats…but foods with fats also had sugar along with them.  So is it fat or sugar?  When Keys did his multivariate linear analysis, he found a correlation in one direction: high fat is associated with heart disease, but not the other: heart disease is associated with high fat.  So the conclusion of avoiding saturated fats is actually not supportable.

Also there are two kinds of LDL, so which kind of LDL cause damage?  Pattern A or Pattern B?   Pattern A is when the LDL moleculres are so bouyant they can’t cause plaque in arteries.  Pattern B are the ones that begin to create plaque. The way to distinguish is through the use of triglyceries and HDL.

If low Triglycerides, and high HDL -> good (Pattern A)

High Triglycerides, low HDL->  bad (Pattern B)

Dietary fat raises HDL (good), sugar raises LDL(bad).  Now the low fat craze has resulted in more sugar, and more transfats.

Biochemistry

  • Fructose 7 times more likely to have the browing reaction (AGE)
  • Fructose does not satiate hunger by suppressing ghrelin
  • Does not stimulate insulin or leptin
  • Hepatic processing is completely different
    • causes metabolic syndrome

Comparisons

  • When eating 2 slices of white bread:80% of that is glucose, which we are designed to eat. Glucagon and Epinephrine convert it to glycogen, which is a nontoxic storage form.  Some of it becomes pyruvate  for mitochondria to make ATP. Some of it could become citrate and goes to 3 enzymes  that turn sugar into fat: Denovo Lipogenesis, which creates VLDL (Bad [heart disease and obesity]). 24 calories can participate in the lipogenesis.
  •  Ethanol(alchohol) is a toxin Alcohol causes acute problems in brain, but frucose does not cause acute problems. 120 calories of ethanol, 24 calories are used up  right away.  96 calories hit liver unlike the 24  in sugar.  Alcohol is converted into aldehydes, and damages protein in liver, but will generate energy.  More Citrate available because more calories in general, so more VLDL.  Liver will try to get rid of it, sometimes in the form of free fatty acids resulting in muscle insulin resistance and diabetes.  Then it generates JUNK1 which creates inflammation.
  • 120 calories of sucrose (orange juice): 20/80 split for glucose, but all fructose molecules will go to liver.  No insulin is made,  We now have 72 calories that must be phosphorylated (so phosphorous is lost), and creates uric acid (gout, and hypertension).  Uric Acid blocks enzyme endothelial NO Synthase, blocking NO.   NO keeps your blood pressure low.   Alpurinol treats gout by treating uric acid and blood pressure went down.

Fructose also repletes glycogen faster than sugar….but this is for elite athletes, not kids.  Original gatorade was terrible, so they added HFCS.  Now we have another path that also makes citrate and therefore VLDL.

Fructose makes fat, Glucose does not.

Fructose makes fat, Glucose does not.

Sugar makes fat, so high sugar diet is a functionally a high fat diet.  ALT is an enzyme that tells you if you have a fatty liver.  The more sugar the more ALT.  JUNK1 inactivates the ability to use the sugar in liver, and makes energy goes into fat cell; increases insulin.  All this causes 8/12 sympoms of chronic ethanol exposure. Biochemically sugar and alcohol are functionally the same

Treatment

  • No juice/sugar beverages
  • Eat Carb with Fiber
  • Wait 20 mintes for before getting another portion
  • Buy screen time 1:1 with physical activity

It works!

Exercise

Is important because it improves insulin sensitivity. reduces stress, make the deNovo lipogenesis ( by increasing the TCA cycle)

Fiber

Antidote to sugar. Fruit is ok because of  fiber and micro nutrients.

  • Reduces carbohydrate absorption:farts
  • Increase rate of transit to illium
  • Short Chain Fatty Acids suppress insulin

Paleo

cures diabetes because of fiber, not because of the meat but because of the fiber in the vegetables.  But if you’d like to cut down on the suga:  FrenchFries, Hash Browns, Chicken McNuggets, Diet Coke, Coffee,Sausage. have no sugar @ McDonalds.

Coke, Beer have same effect on liver

Coke, Beer have same effect on liver.

Soda Belly == Beer Belly

Fructose is a carbohydate, but metabolized as a fat, thus a low fat diet is not a low fat diet.  Should not be GRAS, no studies show that it is safe.  FDA only regulates acute toxins, not chronic toxins.

Summary

 

  • GTT: Insulin Hyper secretion
  • ALT:  amt of liver fat
  • Uric Acid: proxy for sugar consumption
  • Fat makes you fat, but sugar pushes you metabolic syndrome
  • Glucose is good sugar but not that sweet
  • Fructose ontains keto groups that create browining reaction.  Protein get less flexible
  • Fruit is better than juice.  Because fruit has fiber, and slows down sugar absorption
  • Eating less will not work if there is leptin resistance.  Insulin causes this leptin resistance.
    • Eat less sugar/fructose
    • if Hypersecretion fewer carbs
    • exercise creates mitochondria to burn fat
  • Antipsychotic drugs and obesity, T2D
    • Mood Stabilizers causes liver insulin resistance
    • and weight gain
  • We eat too much sugar (toxid doses)
    • comes hidden in processed foods
    • and soft drinks
    • Sugar doesn’t cause obesity, it causes metabolic syndrome
  • Nothing sweet is poisonous…so it is safe
  • Fructose and Glucose together causes more fat than just fructose
    • Fructose goes down lipid pathway
    • Glucose Glycolitic pathway
  • artificial sugar increases weight?
    • no data (stevia)
    • Sugar bolus is coming, buth then insulin doesn’t come out and you end up overeating
  • Every diet regresses to the mean in 2 months.
  • Low Sugar and High fat
  • Yogurt (processed)  is not a health food
  • Liposuction does not remove visceral fat
  • Tumors respond/grow because of insulin
  • Not
    • total number of calories
    • fiber is pushes calories down alimentary canal so not absorbed
    • fats are good for you, while transfat are bad
    • Proteins…you expend more energy breaking down proteins than sugars (lower “net carbs”)
    • two kinds of meat..marbling IS insulin resistance in our food

 

Categories: Inflammation, Liver
%d bloggers like this: