Home > Autism, Condition > DAN to MAPS for Autism Treatment

DAN to MAPS for Autism Treatment

You may have heard of Defeat Autism Now!  or DAN. This group of doctors were giving it their all to find causes and solutions to the Autism epidemic that was and still is affecting our kids.  That group of doctors provided biomedical breakthroughs but apparently did not organize and develop past their burst of research to further develop medical professionals.  Thus MAPS was created; it stands for Medical Academy of Pediatric Special Needs.

In this video from Autism One, Intro to MAPS, you get the background and purpose of MAPS.  Allow me to list my notes for this lecture.


Lecture Notes

  • Most treatments are off label except for Risperadol or Abilify (for irritability)
  • Autism does not have biomarkers so diagnosis is based on behavior
  • Autism likely can have several causes rather than just one or similar combinations
  • Causes might be
    • Mitchondrial dsyfunction
    • Inflammation
    • Oxidative Stress
    • Metabolic problems
      • Inhibition of function
        • e.g. clostridia releases toxin (propionic acid) that inhibits mitochondria, increases inflammation
        • Folate antibodies in the brain
        • Deficiencies (glutathione, iron etc)
  • Shades of grey, not disease but maybe dysfunction.
    • Gluten Intolerance vs Celiac Disease
    • Cerebral Folate Deficiency – treat with high dose folinic acid
    • Hypothyroidism
    • 2/3 of autistic kids have iron deficiency (low ferritin)
    • 1/3 of autistic kids have Low Cholesterol
  • Will use Biomarkers (testable) for
    • Endocrine
    • Methaylation and Transulfuration
    • Oxidative Stress
    • Immune Dysfunction
    • GI Stress
    • Toxicity
    • Mitochondrial Dysfunction
  • Varied treatments up to practitioner but treatments are changing fast
    • How can we get people to keep up
    • Can we create a protocol?
    • But we should be able to identify what is individual and what is more generally successful
    • Should know risk to benefit ratio of any treatment
    • Sometimes genetic tests create passivity when gene is identified even if things may still be helpful
  • MAPS is trying to categorize strengths of evidence into 4 categories
    • A – 2 or more randomized clinical trials (RCT) or 1 systematic review (like the melatonin study!)
    • B – 1 or more RCTs or 2 non RCT
    • C – 1 non RCT or 2 series cases
    • D – inconsistent or no improvement studies
  • Here is a table listing what works in Autism based on studies, only melatonin gets an A.
    • Vitamin C gets a B
    • HBOT gets a B
    • BH4 gets a B too.
  • Other way to evaluate treatement
    • S – Safety
    • T – Tolerable
    • E – Efficacy
    • P – Price
    • S – Simplicity
  • MAPS wants to see behavior as a changeable
  • Wants to understand underlying contribution not just medicate for behavior
  • Type of Medicine
    • Disease Oriented Medicine – lowering of cholesterol, doesn’t mean that life is better
    • Patient Oriented Evidence that Matters — maybe patients lived longer
    • e.g.Methyl B12
      • DOM: Boost Gluathione
      • POEM: Increases Speech
  • About Professonal Development
Categories: Autism, Condition
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