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Inflammation and Depression

December 31, 2012 1 comment
Dahlia 'Inflammation'

Dahlia ‘Inflammation’ (Photo credit: F. D. Richards)

According to this Danish post, inflammation causes depression, which causes inflammation.  Depression causes one to have errant sleep, poor stress management, eating poorly, withdrawl from socials support.  This causes epigenetic changes that increase inflammation.

Danish scientists took a cohort of 73,000 people and measured their levels of C-Reactive Protein (CRP)…a marker for inflammation, and mapped those levels to antidepressant dispensation from a pharmacy, and records of people hospitalized for depression.  (You will never be able to do something like this in the USA). 

They found that people with CRP above 3mg/liter had more antidepressant use and hospitalization than those with values under 1mg/liter.  CRP is made in the liver. While the article says that inflammation may affect serotonin in the brain.  We know that serotonin is also found in the GI tract….right next to that liver.  So it must be affected there as well?

 So many more reasons to monitor inflammation, and reduce it.   I suspect that inflammation is our body overextended.  Designed to solve problems here and there such as in injuries, prolonged stress may lead to continuous inflammation.  So stress reduction may be a great way to reduce CRP and maybe therefore depression..

Liver and Circadian Cycles

December 30, 2012 1 comment

Liver & Onions

There are over 3000 switches that turn genes off or on in the liver on a daily basis.

Did you know that circadian rhythms affect our bodies not just on a global scale, but at the level of individual organs, and even genes? UVA has found two different cycles, with he newest one based on genes that are active in the liver.  These genes are responsive to nutrient intake rather than being light-based like the ones in the brain.

Since the liver is involved in metabolism of cholesterol and fat, this finding may help isolate the switches or combination of swiches that contribute to this processing.

This article states: they discovered that among those switches was chromatin, the protein complex that tightly packages DNA in the cell nucleus. While chromatin is well known for the role it plays in controlling genes, it was not previously suspected of being affected by circadian cycles.

So it is through circadian effect on chromatin that some epigenetic control might be occuring.  Histonic.  No that’s not a misspelling. Histones have been found to be responsible for genetic epression.  We just didn’t know it was based on circadian rhythms!

On that note I’m planning on changing my sleep schedule and go to bed now… before midnight!

Categories: Genetics, Liver, Organ, Sleep

Touch and Move

December 30, 2012 Leave a comment
Massage Faciale © Hélianthal - Office de Touri...

Massage Faciale © Hélianthal – Office de Tourisme de Saint-Jean-de-Luz (Photo credit: Terre et Côte Basques)

YOHAF had a recent show up stress and hormones, I’ve summarized it here for reference.  Please forgive the bulleted summary style!

Massage

Massage releases oxytocin, which reduces fear. Stretching and physical activity with massage add to the effect.

Intervention studies abstract out many other variables such as mood, time, place, practition etc when it comes to massage studies, but why not add these variables back in to suit you.

Moving helps  heal affects of stress.  In this study fruits and vegetables did not address consequences of stress, but movement did.  Rest is also important; need time to recover.

Continous Stress

Stress hormones are also hormones of learning and adaptation, but Downtime is also important to integrate what they’ve learned.

Adrenaline -> Cortisol -> higher blood sugar -> lower immunity healing, digestion, sex hormones go down during acute stressors.  Can present as autoimmune things like Lupus, Thyroidits.  Amygdala grows and hippocampus shrinks.  Now you have chronic inflammation.

Recover by:

  • Be Kind to yourself
  • Eat
  • Rest
  • Walk
  • Avoid Helplessness

 If Cortisol is high/low, sex and thyroid hormones are affected.   If sex hormones are lowered, choleserol will go up. Alcohol raises estrogen in men. 

Stress causes people do want comfort foods raise insulin and cortisol.  Now there is depression and weight gain.  Now progesterone gets low and can cause acne and PCOS.  Sustained stress causes depression and lowered TSH. Pharmaceuticals used to push you when you need rest then messes up other nutrients, like vitamins, carnitine etc.

Movement

Exercise increases metabolism for up to 4 hours, it can also make you smarter.  Around 20-30 minutes of exercise upregulates your metabolism and switches to burning fat!  If stress makes fat, then exercising burns it while it’s being made.  But again be gentle with yourself. If you are in stress mode, exercising more than you can handle can create even more stress.

  • Wireless is also a stressor
  • Socialize
  • Take an iron-free vitamin supplement, especially Vitamin C
  • and minerals
  • Omega 3s from Vegan sources
  • Meditation
  • Art

Healing with Emotion

December 28, 2012 Leave a comment

Gregg Braden is a scientist turned woowoo, but he backs up his woo woo with Science.  I love to listen to him and Bruce Lipton.  I had seen the 3 minute version before, but Gregg explains a bit more of how it works too.

What this amazing video of a sonogram of a woman being treated for bladder cancer.  You can see the tumor shrink away!

Categories: Cancer, Woowoo

DAN to MAPS for Autism Treatment

December 27, 2012 Leave a comment

You may have heard of Defeat Autism Now!  or DAN. This group of doctors were giving it their all to find causes and solutions to the Autism epidemic that was and still is affecting our kids.  That group of doctors provided biomedical breakthroughs but apparently did not organize and develop past their burst of research to further develop medical professionals.  Thus MAPS was created; it stands for Medical Academy of Pediatric Special Needs.

In this video from Autism One, Intro to MAPS, you get the background and purpose of MAPS.  Allow me to list my notes for this lecture.

MAPS

Lecture Notes

  • Most treatments are off label except for Risperadol or Abilify (for irritability)
  • Autism does not have biomarkers so diagnosis is based on behavior
  • Autism likely can have several causes rather than just one or similar combinations
  • Causes might be
    • Mitchondrial dsyfunction
    • Inflammation
    • Oxidative Stress
    • Metabolic problems
      • Inhibition of function
        • e.g. clostridia releases toxin (propionic acid) that inhibits mitochondria, increases inflammation
        • Folate antibodies in the brain
        • Deficiencies (glutathione, iron etc)
  • Shades of grey, not disease but maybe dysfunction.
    • Gluten Intolerance vs Celiac Disease
    • Cerebral Folate Deficiency – treat with high dose folinic acid
    • Hypothyroidism
    • 2/3 of autistic kids have iron deficiency (low ferritin)
    • 1/3 of autistic kids have Low Cholesterol
  • Will use Biomarkers (testable) for
    • Endocrine
    • Methaylation and Transulfuration
    • Oxidative Stress
    • Immune Dysfunction
    • GI Stress
    • Toxicity
    • Mitochondrial Dysfunction
  • Varied treatments up to practitioner but treatments are changing fast
    • How can we get people to keep up
    • Can we create a protocol?
    • But we should be able to identify what is individual and what is more generally successful
    • Should know risk to benefit ratio of any treatment
    • Sometimes genetic tests create passivity when gene is identified even if things may still be helpful
  • MAPS is trying to categorize strengths of evidence into 4 categories
    • A – 2 or more randomized clinical trials (RCT) or 1 systematic review (like the melatonin study!)
    • B – 1 or more RCTs or 2 non RCT
    • C – 1 non RCT or 2 series cases
    • D – inconsistent or no improvement studies
  • Here is a table listing what works in Autism based on studies, only melatonin gets an A.
    • Vitamin C gets a B
    • HBOT gets a B
    • BH4 gets a B too.
  • Other way to evaluate treatement
    • S – Safety
    • T – Tolerable
    • E – Efficacy
    • P – Price
    • S – Simplicity
  • MAPS wants to see behavior as a changeable
  • Wants to understand underlying contribution not just medicate for behavior
  • Type of Medicine
    • Disease Oriented Medicine – lowering of cholesterol, doesn’t mean that life is better
    • Patient Oriented Evidence that Matters — maybe patients lived longer
    • e.g.Methyl B12
      • DOM: Boost Gluathione
      • POEM: Increases Speech
  • About Professonal Development
Categories: Autism, Condition

Abdominal GI webinar by Kurt Woeller

December 27, 2012 Leave a comment

He’s taken a  lot of information in research areas and combined it together in a webinar.   It should be available for a few more days and then you have to subscribe to it. But here are my notes; I didn’t note dosages because I don’t know your current setup.  Let me know if you need any explanation of what is here, I will do my best.

Constipation

Abdominal X-Ray might find impacted colon.  Could be caused by too few digestive enzymes.  CDSA testing can find alastate which is a reflection of pancreatic output.  Can take enzymes

  • Peptizyde-Gluten/Casein
  • ZymePrime for general

Could be an HCL deficiency, bu this is stomach acid so I’ve not gotten comfortable taking it.

Normal bowel movements are 2-3 times per day. These days we can tolerate once per day.  If less than that we must address it.

Irritability and moodiness can result.  Stools should be soft and fall to the bottom of the toilet.

Interventions

  • Worms (pin and round), morning coughing, worstening behavior during full moon
    • Vermox 100mg chewables (prescription)
  • and bacteria can cause gas, we usually think Candida, bu it may be others.
    • Black Walnut Extract.  Don’t take this willy nilly it is powerful. 
  • Can take High Dose Vitamin C, if no oxalate problems
  • High dose probiotics to improve motility
    • VSL3
    • Therbiotic complee
  • Prebiotic
  • Magnesium
  • Aloe Vera juice
  • Fiber

Diarrhea

  • Food if intermittent
  • Yeast
  • Bacteria — continuous
  • Parasites-suspect if cyclical
    • Flagyl for clostridia
    • Alinia for giardi, crytospiridium
      •  still under patent
  • Alternating
    • fecal plug or
    • chronic inflammation
  • Gi Specialist with pillcam: Krigsman www.autismgi.com

Anxiety

  • GABA
  • Theanine (can work with GABA)
  • Inositol – good for OCD (also good with GABA)
  • Magnesium Citrate
  • 5HTP
  • Oxytocin (available sublingually)
  • Respen A- contains Rauwolfia  but is low dose.  Rauwolfia used initially for hypertension. Could cause irritability and low calcium cramping at higher doses. It upregulates MAO-A which reduces serotonin.  Makes kids more empathetic and happier.
  • Namenda-used in Alzheimers
  • Gluten or Casein Infraction
    • Pepcid AC
    • Epsom Salt Cream or Bath
    • Peptizyde (DPP-IV) enzyme
    • Activated Charcoal
    • Alka Seltzer Gold

Hand Flapping

  • Ammonia causes hand flapping
  • treated with Alpha-Ketoglutaric Acid
  • Activated Charcoal may cause constipation so take
    • Magnesium

Hyperactivity

  • Diet
    • wheat
    • soy
    • dairy
    • artifical colors and flavors
      • Feingold Diet
    • Salicylates and Phenols
  • Supplements
    • Cod Liver Oil
    • Active forms of B vitamins
    • Yeast overgrowh
    • Methyl Folate
    • Methyl B12
    • Pycnogenol
    • Taurine
    • No Fenol enzymes
    • Nicotine Patch
      • Jeff Bradstreed MD proposed
      • reduces neurological inflammation
      • improves
        • hyperactivity
        • attention
        • focus
        • memory
        • Stimulate nicotince receptors that modulates acetylcholine
      • 1/4 to 1/2 7mg patch
      • Can apply or 24 hours or 16 if hyperactivity

Aggression

  • hypoglycemic
  • Food or Environmental
  • Constipation
  • Clostridia rom Organic Acid Test
    • HPHPA marker elevated means dopamine
    • Culturelle
    • Sacchromyces boulardii
    • Antibiotics
      • Flagyl
      • Alinia
      • Vancomycin
      • Only treats bacteria but not spores
        • VSL3 does
  • High Oxalates
    • OAT checks this too
    • causes kidney stones
    • VSL #3
    • Cal/Mag with meals
    • Fibromyalgia can have oxalate problems

Sleep

  • less sugar in evening
  • Peptides?
  • Iron deficiency or ferritin > 50
  • Avoid zinc and B6
  • Avoid Full Spectrum light bulbs, it suppresses melatonin
  • Chamomile, Passion flower or Valerian
  • Melatonin or Melatonin PR
  • 5-HTP
  • Tryptophan

Stimming

  • Yeast
  • Allergens
  • Soy etc
  • Chlorine from swimming
  • Remedies
    • CLO for visual stims
    • Tauring, Zinc, Glycien
    • GABA and lithium
    • Theanine
    • RespenA
    • Namenda

So you can always reach DrWoeller.com.

Categories: Anxiety, Genetics

Fish Oil Bad for you?

December 24, 2012 Leave a comment

We all know how wonderful fish oil is as an anti-inflammatory, improves blood pressure,  improves mood, and a host of other things.  So am I really saying that Fish Oil could be bad for you?

FIsh Oil Bad For You?

But there may be concerns with taking too much or any!

  1. For many years we have known to be wary of Fish Oils that were not specifically tested for mercury contamination.  You can now find many products that say they are mercury free.
  2. Another problem is oxidative stress.    Omega 3 oils are delicate they can break down easily.  Remember they are from COLD water fish.  Having your bottle sit next to a toaster oven or a blowing vent can easily begin to breakdown
  3. Maybe not in a physical way, but if you are vegetarian you can’t really have it at all can you?

But to address these in reverse order, you can easily start taking vegan Omega 3s directly from the algae that produce them.

Ok but then what about Oxidative Stress? We see that too much Omega 3s can decrease lifespan.  However the authors of the study promote the addition of antioxidants, not the removal of the oils.  You can limit the dangers of oxidative stress by taking astaxanthin, found in Krill Oil. In addition another study shows that oxidative stress was actually reduced when specifically using OmaCor capsules. These are prescription fish oils that have been altered and purified. 

This is important when it comes  to well known problems with mercury in fish oil.  But in industrial fish there is also a concern about arsenic.  This is where the vegan oils show the promise of bypassing the mercury and aresenic contamination.

All in all, the dynamics may be dependent on the type of DHA/EPA you are getting, but it could also be dose dependent, a safe bet would be taking no more than 1g per day.  A safer bet would be to get your oils directly from the algae that produces the EFAs.

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